Trial reportThe Journal of pediatrics2018
Acute Responses to Diuretic Therapy in Extremely Low Gestational Age Newborns: Results from the Prematurity and Respiratory Outcomes Program Cohort Study.
Trial report in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01435187 (Prematurity and Respiratory Outcomes Program), which is not on this map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prematurity and Respiratory Outcomes Program (PROP) Core Database Protocol
Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Outpatient Diuretic Use and Respiratory Outcomes in Children with Bronchopulmonary Dysplasia During the First Three Years of Life.The Journal of pediatrics · 2025Article
- The Use of Diuretics in Infants with Established or Evolving Bronchopulmonary Dysplasia and Its Impact on the Duration of Home Oxygen Therapy.Thoracic research and practice · 2024Article
- Weaning and extubation from neonatal mechanical ventilation: an evidenced-based review.BMC pulmonary medicine · 2022Review
- Cumulative Doses Predict the Risk of Furosemide-Induced Electrolyte Abnormalities in Critically Ill Neonates.Therapeutics and clinical risk management · 2022Article
- World Prematurity Day: it takes an NIH village to prevent preterm birth and improve treatments for preterm infants.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Optimizing respiratory management in preterm infants: a review of adjuvant pharmacotherapies.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Use of diuretics in the neonatal period.Pediatric nephrology (Berlin, Germany) · 2021Review
- An Update on the Prevention and Management of Bronchopulmonary Dysplasia.Pediatric health, medicine and therapeutics · 2021Review
- Bronchopulmonary Dysplasia: Then, Now, and Next.Pediatric allergy, immunology, and pulmonology · 2020Review
- Furosemide use in Italian neonatal intensive care units: a national survey.Italian journal of pediatrics · 2020Article
- Furosemide Exposure and Prevention of Bronchopulmonary Dysplasia in Premature Infants.The Journal of pediatrics · 2019Article
- Randomized comparison of continuous versus intermittent bolus furosemide in neonatal heart failure.Annals of pediatric cardiologyArticle
Corrections and comments
- Commented on byReply.2018
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine if daily respiratory status improved more in extremely low gestational age (GA) premature infants after diuretic exposure compared with those not exposed in modern neonatal intensive care units. STUDY
designThe Prematurity and Respiratory Outcomes Program (PROP) was a multicenter observational cohort study of 835 extremely premature infants, GAs of 23
resultsInfants in the diuretic exposed group of PROP were of lower mean GA and lower mean birth weight (P < .0001). Compared with infants unexposed to diuretics, the probability (adjusted for infant characteristics including GA, birth weight, sex, and respiratory status before receiving diuretics) that the exposed infants were on a higher level of respiratory support was significantly greater (OR, >1) for each day after the initial day of diuretic exposure.
conclusionsOur analysis did not support the ability of diuretics to substantially improve the extremely premature infant's respiratory status. Further study of both safety and efficacy of diuretics in this setting are warranted.
trial registrationClinicaltrials.gov: NCT01435187.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.