Evidence map›Paper›PMID 29597876›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2018

AMPKα2 deficiency enhanced susceptibility to ventricular arrhythmias in mice by the role of β-adrenoceptor signaling.

Hong Cao, Xin Wang, Shaozheng Ying, Congxin Huang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hong Cao1 Departments of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Xin Wang1 Departments of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Shaozheng Ying1 Departments of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Congxin Huang1 Departments of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
Renmin Hospital of Wuhan University · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AMP-activated protein kinase-α2 is the main catalytic subunit of the heart, which is mainly located in cardiac myocytes. The effect of AMP-activated protein kinase-α2 on the cardiac electrophysiology is barely studied. From the previous study, it is possible that AMP-activated protein kinase-α2 may have some effect on the electrophysiology of the heart. To prove the hypothesis, we used the AMP-activated protein kinase-α2 knockout (AMPKα2

Indexed as

Signal TransductionAdrenergic beta-1 Receptor AntagonistsAMP-Activated Protein KinasesAnimalsArrhythmias, CardiacCatecholaminesMaleMetoprololMiceMice, KnockoutReceptors, Adrenergic, betaAdrenergic beta-1 Receptor AntagonistsAMP-Activated Protein KinasesCatecholaminesMetoprololPrkaa2 protein, mouseReceptors, Adrenergic, betaAMP-activated protein kinase-α2arrhythmiascatecholaminemiceβ-adrenoceptor antagonist

Identifiers

PMID29597876
PMCPMC6378509
OpenAlexW2794824070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.