ArticleSensors (Basel, Switzerland)2018
Experimental Study of the Oriented Immobilization of Antibodies on Photonic Sensing Structures by Using Protein A as an Intermediate Layer.
Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Silicon Microring Resonator Biosensor for Detection of Nucleocapsid Protein of SARS-CoV-2.Sensors (Basel, Switzerland) · 2024Article
- Biosensors Based on Stanniocalcin-1 Protein Antibodies Thin Films for Prostate Cancer Diagnosis.Biosensors · 2023Article
- Performance improvement of a silicon nitride ring resonator biosensor operated in the TM mode at 1310 nm.Biomedical optics express · 2021Article
- Advances in Electrochemical and Acoustic Aptamer-Based Biosensors and Immunosensors in Diagnostics of Leukemia.Biosensors · 2021Review
- Porous Silicon Optical Devices: Recent Advances in Biosensing Applications.Sensors (Basel, Switzerland) · 2021Review
- Optical Biosensors Based on Silicon-On-Insulator Ring Resonators: A Review.Molecules (Basel, Switzerland) · 2019Review
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Authors and funding
6 authors.
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Abstract
A proper antibody immobilization on a biosensor is a crucial step in order to obtain a high sensitivity to be able to detect low target analyte concentrations. In this paper, we present an experimental study of the immobilization process of antibodies as bioreceptors on a photonic ring resonator sensor. A protein A intermediate layer was created on the sensor surface in order to obtain an oriented immobilization of the antibodies, which enhances the interaction with the target antigens to be detected. The anti-bovine serum albumin (antiBSA)-bovine serum albumin (BSA) pair was used as a model for our study. An opto-fluidic setup was developed in order to flow the different reagents and, simultaneously, to monitor in real-time the spectral response of the photonic sensing structure. The antiBSA immobilization and the BSA detection, their repeatability, and specificity were studied in different conditions of the sensor surface. Finally, an experimental limit of detection for BSA recognition of only 1 ng/mL was obtained.
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