Evidence map›Paper›PMID 29597249›Full record

ReviewCancers2018

The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas.

Ines Garces de Los Fayos Alonso, Huan-Chang Liang, Suzanne D Turner, Sabine Lagger, Olaf Merkel, Lukas Kenner

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 172 citations in OpenAlex.

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  11. Transcriptomic Differences Between Immortalized Oral and Skin Keratinocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ines Garces de Los Fayos AlonsoLudwig Boltzmann Institute for Cancer Research, 1090 Vienna, Austria. Ines.Garces@lbicr.lbg.ac.at.
Huan-Chang LiangClinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria. huan-chang.liang@meduniwien.ac.at.ORCID 0000-0003-2612-3714
Suzanne D TurnerDepartment of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB21QP, UK. sdt36@cam.ac.uk.ORCID 0000-0002-8439-4507
Sabine LaggerUnit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria. Sabine.Lagger@vetmeduni.ac.at.
Olaf MerkelClinical Institute of Pathology, Medical University of Vienna, 1090 Vienna, Austria. Olaf.merkel@meduniwien.ac.at.
Lukas KennerLudwig Boltzmann Institute for Cancer Research, 1090 Vienna, Austria. Lukas.Kenner@meduniwien.ac.at.
University of Veterinary Medicine Vienna · ATMedical University of Vienna · ATUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their discovery, the role of AP-1 TFs in cancer development has been extensively analysed. Multiple in vitro and in vivo studies have highlighted the complexity of these TFs, mainly due to their cell-type specific homo- or hetero-dimerization resulting in diverse transcriptional response profiles. However, as a result of the increasing knowledge of the role of AP-1 TFs in disease, these TFs are being recognized as promising therapeutic targets for various malignancies. In this review, we focus on the impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma.

Indexed as

Activator Protein-1 (AP-1)Anaplastic Large Cell Lymphoma (ALCL)CD-30Classical Hodgkin Lymphoma (CHL)Peripheral T-cell Lymphoma (PTCL)Transcription Factors (TFs)

Identifiers

PMID29597249
PMCPMC5923348
OpenAlexW2794898956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.