Evidence map›Paper›PMID 29596964›Full record

ArticleBone2018

Low bone density and fractures before and after pediatric lung transplantation.

Melissa S Putman, Tregony Simoneau, Henry A Feldman, Alexandra Haagensen, Debra Boyer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Melissa S PutmanDivision of Endocrinology, Boston Children's Hospital, Boston, MA, United States; Endocrine Unit, Massachusetts General Hospital, Boston, MA, United States. Electronic address: melissa.putman@childrens.harvard.edu.
Tregony SimoneauDepartment of Pulmonary Medicine, Connecticut Children's Medical Center, Hartford, CT, United States.
Henry A FeldmanClinical Research Center, Boston Children's Hospital, Boston, MA, United States.
Alexandra HaagensenDivision of Endocrinology, Boston Children's Hospital, Boston, MA, United States.
Debra BoyerDivision of Respiratory Diseases, Boston Children's Hospital, Boston, MA, United States.
Boston Children's Hospital · USConnecticut Children's Medical Center · US

Funding

Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
The Endocrine Complications of Cystic Fibrosis: the Role of CFTRK23DK102600 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI PUTMAN, MELISSA SUSAN · 2015 to 2018
$634k
NCATS NIH HHS UL1 TR000170NIDDK NIH HHS K23 DK102600
6 · The paper itself

Abstract

introductionChildren undergoing lung transplant are at risk for low bone mineral density (BMD) and fractures. The effect of lung transplantation on bone health in pediatric patients is unknown. MATERIALS AND

methodsWe performed a retrospective chart review of all patients ages 2-21 years who underwent lung transplantation at our hospital from January 2000 to January 2015.

results51 patients were studied. At the time of transplant evaluation, BMD Z-score was -2.2 ± 1.4, and 59% of patients had low BMD. BMD Z-score declined in the first year after treatment and returned to near-baseline by the third post-transplant year. Fractures occurred in 9 patients (18%) before and 15 patients (29%) after transplant. Bisphosphonate use was associated with improvement in BMD Z-score and lower mortality risk.

conclusionsPediatric patients had a high prevalence of low BMD at the time of lung transplant evaluation. BMD Z-scores declined in the year after transplant and returned to the pre-transplant level by the third post-transplant year while remaining below normal levels. Fractures were common at sites associated with significant morbidity. These findings support efforts to optimize bone health before and after pediatric lung transplantation, and future studies are needed to evaluate the role of bisphosphonates in these patients.

Indexed as

Bone DensityAdolescentAsian PeopleBlack or African AmericanChildChild, PreschoolDiphosphonatesFemaleFractures, BoneHispanic or LatinoHumansLung TransplantationMalePrevalenceRetrospective StudiesWhite PeopleDiphosphonatesBisphosphonateBone mineral densityFractureLung transplantationPediatric

Identifiers

PMID29596964
PMCPMC5931383
OpenAlexW2795281138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.