Evidence map›Paper›PMID 29596916›Full record

ArticleJournal of molecular biology2018

Some Surprising Implications of NMR-directed Simulations of Substrate Recognition and Binding by Cytochrome P450

Eliana K Asciutto, Thomas C Pochapsky

Abstract read
In one paragraph

Article in Journal of molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Entropic contribution to enhanced thermal stability in the thermostable P450 CYP119.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eliana K AsciuttoSchool of Science and Technology, UNSAM and CONICET, Campus Migueletes, 25 de Mayo y Francia, Buenos Aires, Argentina.
Thomas C PochapskyDepartment of Chemistry and Rosenstiel Basic Biomedical Sciences Research Institute, MS 015, Brandeis University, 415 South St., Waltham, MA 02454-9110, USA. Electronic address: pochapsk@brandeis.edu.

Funding

STRUCTURE AND DYNAMICS OF METAL-CONTAINING PROTEINSR01GM044191 · NIGMS · BRANDEIS UNIVERSITY · PI POCHAPSKY, THOMAS CHARLES · 1995 to 2012
$3.4M
NIGMS NIH HHS R01 GM044191
6 · The paper itself

Abstract

Cytochrome P450

Indexed as

CamphorCatalytic DomainCrystallography, X-RayCytochrome P-450 Enzyme SystemHydroxylationModels, MolecularMolecular Dynamics SimulationMutationNuclear Magnetic Resonance, BiomolecularProtein Structure, SecondarySubstrate SpecificityCamphorCytochrome P-450 Enzyme Systemanisotropic network modelcytochrome P450 stereospecificityperturbation response scanningresidual dipolar couplingssolution conformational ensembles

Identifiers

PMID29596916
PMCPMC5916322

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.