ReviewFrontiers in neuroendocrinology2018
The short-term stress response - Mother nature's mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity.
Review in Frontiers in neuroendocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
107 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A dual-index framework for cold atmospheric plasma dosing: A meta-analysis of parametric control from volumetric redox flux to redox homeostatic status.Redox biology · 2026Pooled it
- Pooled it
- An exploratory study on the changes in immune and metabolic parameters by 10 weeks of yoga intervention among medical students.Scientific reports · 2025Trial
- βBrain, behavior, and immunity · 2018Trial
- Psychological and biological long-term consequences of trauma in the Yazidi population displaced from Shingal after the genocide.European journal of psychotraumatology · 2026Article
- The Sentinel Sleep Theory: Unweaving the biological function of REM sleep.Sleep medicine: X · 2026Article
- Stress, needs, and behaviour: understanding chronic stress in pet domestic dogs (Canis lupus familiaris) from the prism of needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two-Hit Stress Model.Journal of sleep research · 2026Article
- Article
- Stress and the Immune System: Insights From Psychoneuroimmunology.Physiological research · 2026Review
- The Many Faces of Stress: Preliminary Validation of a Remote Photoplethysmography-Based Tool for Psychophysiological Stress and Emotional Distress Monitoring.Healthcare (Basel, Switzerland) · 2026Article
- [Psychological distress and cancer: facts and myths in the light of scientific evidence].Magyar onkologia · 2026Review
- The Effect of Environmental Vulnerability on Family Caregiver Health.Oncology nursing forum · 2026Article
- Article
- Learning from plants: is it possible to make an animal organism a non-host for cancer?Frontiers in oncology · 2026Article
- Burn patients' perceptions of skin grafting in China: a single-center retrospective cohort study with paired pre-post assessment.Frontiers in public health · 2026Article
- Conceptual qualitative system dynamics model for simulation of perceived workload, stress and performance from industrial work content.PloS one · 2026Article
- The effects of motivational verbal phrases on isoinertial force production and sustained force output: a comparison of positive and negative conditions.Frontiers in psychology · 2026Article
- No Effect in Plasma Corticosterone Levels After Observation of Diseased Conspecifics.Integrative organismal biology (Oxford, England) · 2026Article
- Naturalistic psychedelic use and changes in depressive symptoms.Journal of affective disorders · 2025Observational
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Our group has proposed that in contrast to chronic stress that can have harmful effects, the short-term (fight-or-flight) stress response (lasting for minutes to hours) is nature's fundamental survival mechanism that enhances protection and performance under conditions involving threat/challenge/opportunity. Short-term stress enhances innate/primary, adaptive/secondary, vaccine-induced, and anti-tumor immune responses, and post-surgical recovery. Mechanisms and mediators include stress hormones, dendritic cell, neutrophil, macrophage, and lymphocyte trafficking/function and local/systemic chemokine and cytokine production. Short-term stress may also enhance mental/cognitive and physical performance through effects on brain, musculo-skeletal, and cardiovascular function, reappraisal of threat/anxiety, and training-induced stress-optimization. Therefore, short-term stress psychology/physiology could be harnessed to enhance immuno-protection, as well as mental and physical performance. This review aims to provide a conceptual framework and targets for further investigation of mechanisms and conditions under which the protective/adaptive aspects of short-term stress/exercise can be optimized/harnessed, and for developing pharmacological/biobehavioral interventions to enhance health/healing, and mental/cognitive/physical performance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.