ArticleExperimental neurology2018
Spontaneous respiratory plasticity following unilateral high cervical spinal cord injury in behaving rats.
Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed.
- Perineuronal Net Changes Reveal a Distinct Right and Left Spinal Phrenic Circuit.Journal of neurotrauma · 2025Article
- Impact of upper cervical spinal cord hemisection on diaphragm neuromotor control.Journal of neurophysiology · 2025Article
- An update on spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2025Review
- Review
- A Simple, Low-Cost Implant for Reliable Diaphragm EMG Recordings in Awake, Behaving Rats.eNeuro · 2025Article
- Hypercapnia impacts neural drive and timing of diaphragm neuromotor control.Journal of neurophysiology · 2024Article
- Identification of eupneic breathing using machine learning.Journal of neurophysiology · 2024Article
- Sex differences in spontaneous respiratory recovery following chronic C2 hemisection.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Assessing Functional Recovery of Eupneic Diaphragm Activity Following Unilateral Cervical Spinal Cord Injury in Rats.Journal of visualized experiments : JoVE · 2024Article
- Ampakines increase diaphragm activation following mid-cervical contusion injury in rats.Experimental neurology · 2024Article
- V2a neurons restore diaphragm function in mice following spinal cord injury.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cervical spinal cord hemisection impacts sigh and the respiratory reset in male rats.Physiological reports · 2024Article
- Contrasting Experimental Rodent Aftercare With Human Clinical Treatment for Cervical Spinal Cord Injury: Bridging the Translational "Valley of Death".Journal of neurotrauma · 2023Review
- Routine hypercapnic challenge after cervical spinal hemisection affects the size of phrenic motoneurons.Scientific reports · 2023Article
- Effects of C2 hemisection on respiratory and cardiovascular functions in rats.Neural regeneration research · 2023Article
- Automated evaluation of respiratory signals to provide insight into respiratory drive.Respiratory physiology & neurobiology · 2022Article
- Ampakines Stimulate Diaphragm Activity after Spinal Cord Injury.Journal of neurotrauma · 2021Article
- Oxygen transport kinetics underpin rapid and robust diaphragm recovery following chronic spinal cord injury.The Journal of physiology · 2021Article
- Effects of aerobic exercise training on muscle plasticity in a mouse model of cervical spinal cord injury.Scientific reports · 2021Article
- Ampakines stimulate phrenic motor output after cervical spinal cord injury.Experimental neurology · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Unilateral cervical C2 hemisection (C2Hx) is a classic model of spinal cord injury (SCI) for studying respiratory dysfunction and plasticity. However, most previous studies were performed under anesthesia, which significantly alters respiratory network. Therefore, the goal of this work was to assess spontaneous diaphragm recovery post-C2Hx in awake, freely behaving animals. Adult rats were chronically implanted with diaphragm EMG electrodes and recorded during 8 weeks post-C2Hx. Our results reveal that ipsilateral diaphragm activity partially recovers within days post-injury and reaches pre-injury amplitude in a few weeks. However, the full extent of spontaneous ipsilateral recovery is significantly attenuated by anesthesia (ketamine/xylazine, isoflurane, and urethane). This suggests that the observed recovery may be attributed in part to activation of NMDA receptors which are suppressed by anesthesia. Despite spontaneous recovery in awake animals, ipsilateral hemidiaphragm dysfunction still persists: i) Inspiratory bursts during basal (slow) breathing exhibit an altered pattern, ii) the amplitude of sighs - or augmented breaths - is significantly decreased, and iii) the injured hemidiaphragm exhibits spontaneous events of hyperexcitation. The results from this study offer an under-appreciated insight into spontaneous diaphragm activity and recovery following high cervical spinal cord injury in awake animals.
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