Evidence map›Paper›PMID 29596586›Full record

ArticleCardiovascular research2018

A new strategy to decrease cardiac injury in aged heart following ischaemia-reperfusion: enhancement of the interaction between AMPK and SIRT1.

Qun Chen, Edward J Lesnefsky

Open access · bronzeAbstract readEditorialComment
In one paragraph

Article in Cardiovascular research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Energy metabolism homeostasis in cardiovascular diseases.Journal of geriatric cardiology : JGC · 2021
    Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Qun ChenDepartment of Medicine, Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Edward J LesnefskyDepartment of Medicine, Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Virginia Commonwealth University · US

Funding

activation of mitochondrial calpain augments cardiac injury in aged heartsR21AG054975 · NIA · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHEN, QUN · 2017 to 2018
$433k
Reduction of cardiac injury by targeting damaged mitochondria during reperfusionI01BX001355 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI LESNEFSKY, EDWARD J · 2012 to 2025
–
BLRD VA I01 BX001355NIA NIH HHS R21 AG054975
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Reperfusion InjurySirtuin 1AMP-Activated Protein KinasesHumansMyocardiumMyocytes, CardiacAMP-Activated Protein KinasesSIRT1 protein, humanSirtuin 1

Identifiers

PMID29596586
PMCPMC5909644
OpenAlexW2795058419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.