ArticlePloS one2018
Sensitivity of different MRI sequences in the early detection of melanoma brain metastases.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Radiomics for risk stratification in brain metastases: potential in melanoma brain metastases.Clinical & experimental metastasis · 2026Article
- Artificial intelligence-amplified contrast enhancement in brain magnetic resonance imaging for improving image quality and lesion visualization: a prospective pilot study.Quantitative imaging in medicine and surgery · 2026Article
- The evolving landscape of brain metastasis: volume II.Trends in cancer · 2026Review
- Identification of the pathological subtypes of lung cancer brain metastases with multiparametric MRI radiomics: A feasibility study.Scientific reports · 2025Article
- More than Just Skin-Deep: A Review of Imaging's Role in Guiding CAR T-Cell Therapy for Advanced Melanoma.Diagnostics (Basel, Switzerland) · 2023Review
- The Role and Potential ofDiagnostics (Basel, Switzerland) · 2022Review
- Melanoma brain metastasis mimicking cortical laminar necrosis.Surgical neurology international · 2022Article
- What to Trust, PSA or [Research and reports in urology · 2021Article
- Ferumoxytol-Enhanced MRI Is Not Inferior to Gadolinium-Enhanced MRI in Detecting Intracranial Metastatic Disease and Metastasis Size.AJR. American journal of roentgenology · 2020Article
- Melanoma Radiological Surveillance: A Review of Current Evidence and Clinical Challenges.The Yale journal of biology and medicine · 2020Review
- Accelerated Post-contrast Wave-CAIPI T1 SPACE Achieves Equivalent Diagnostic Performance Compared With Standard T1 SPACE for the Detection of Brain Metastases in Clinical 3T MRI.Frontiers in neurology · 2020Article
- Recognition of Brain Metastases Using Gadolinium-Enhanced SWI MRI: Proof-of-Concept Study.Frontiers in neurology · 2020Article
- Clinical Value of Susceptibility Weighted Imaging of Brain Metastases.Frontiers in neurology · 2020Review
- Neoadjuvant Stereotactic Radiosurgery: a Further Evolution in the Management of Brain Metastases.Current oncology reports · 2019Review
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAfter the emergence of new MRI techniques such as susceptibility- and diffusion-weighted imaging (SWI and DWI) and because of specific imaging characteristics of melanoma brain metastases (MBM), it is unclear which MRI sequences are most beneficial for detection of MBM. This study was performed to investigate the sensitivity of six clinical MRI sequences in the early detection of MBM.
methodsMedical records of all melanoma patients referred to our center between November 2005 and December 2016 were reviewed for presence of MBM. Analysis encompassed six MRI sequences at the time of initial diagnosis of first or new MBM, including non-enhanced T1-weighted (T1w), contrast-enhanced T1w (ceT1w), T2-weighted (T2w), T2w-FLAIR, susceptibility-weighted (SWI) and diffusion-weighted (DWI) MRI. Each lesion was rated with respect to its conspicuity (score from 0-not detectable to 3-clearly visible).
resultsOf 1210 patients, 217 with MBM were included in the analysis and up to 5 lesions per patient were evaluated. A total of 720 metastases were assessed and all six sequences were available for 425 MBM. Sensitivity (conspicuity ≥2) was 99.7% for ceT1w, 77.0% for FLAIR, 64.7% for SWI, 61.0% for T2w, 56.7% for T1w, and 48.4% for DWI. Thirty-one (7.3%) of 425 lesions were only detectable by ceT1w but no other sequence.
conclusionsContrast-enhanced T1-weighting is more sensitive than all other sequences for detection of MBM. Disruption of the blood-brain-barrier is consistently an earlier sign in MBM than perifocal edema, signal loss on SWI or diffusion restriction.
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