Evidence map›Paper›PMID 29596462›Full record

ArticlePloS one2018

Racial disparities in the prevalence and control of hypertension among a cohort of HIV-infected patients in the southeastern United States.

Greer A Burkholder, Ashutosh R Tamhane, Monika M Safford, Paul M Muntner, Amanda L Willig, James H Willig, James L Raper, Michael S Saag, Michael J Mugavero

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Weight Gain After Antiretroviral Therapy Initiation and Subsequent Risk of Metabolic and Cardiovascular Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Greer A BurkholderDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.ORCID 0000-0001-7185-3025
Ashutosh R TamhaneDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Monika M SaffordDivision of General Internal Medicine, Weill Cornell Medical College, New York City, New York, United States of America.
Paul M MuntnerDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Amanda L WilligDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
James H WilligDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
James L RaperDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Michael S SaagDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Michael J MugaveroDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
University of Alabama at Birmingham · USCornell University · US

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Enhancing information, motivation, and behavioral skills to promote antihypertensive medication adherence among persons living with HIVK23HL126570 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURKHOLDER, GREER A · 2015 to 2019
$914k
NHLBI NIH HHS K23 HL126570NIAID NIH HHS P30 AI027767NIAID NIH HHS R24 AI067039NIH HHS 1R24 AI067039-1NIH HHS P30-AI27767
6 · The paper itself

Abstract

backgroundAfrican Americans are disproportionately affected by both HIV and hypertension. Failure to modify risk factors for cardiovascular disease and chronic kidney disease such as hypertension among HIV-infected patients may attenuate the benefits conferred by combination antiretroviral therapy. In the general population, African Americans with hypertension are less likely to have controlled blood pressure than whites. However, racial differences in blood pressure control among HIV-infected patients are not well studied.

methodsWe conducted a cross-sectional study evaluating racial differences in hypertension prevalence, treatment, and control among 1,664 patients attending the University of Alabama at Birmingham HIV Clinic in 2013. Multivariable analyses were performed to calculate prevalence ratios (PR) with 95% confidence intervals (CI) as the measure of association between race and hypertension prevalence and control while adjusting for other covariates.

resultsThe mean age of patients was 47 years, 77% were male and 54% African-American. The prevalence of hypertension was higher among African Americans compared with whites (49% vs. 43%; p = 0.02). Among those with hypertension, 91% of African Americans and 93% of whites were treated (p = 0.43). Among those treated, 50% of African Americans versus 60% of whites had controlled blood pressure (systolic blood pressure <140 mmHg and diastolic blood pressure <90 mmHg) (p = 0.007). After multivariable adjustment for potential confounders, prevalence of hypertension was higher among African Americans compared to whites (PR 1.25; 95% CI 1.12-1.39) and prevalence of BP control was lower (PR 0.80; 95% CI 0.69-0.93).

conclusionsDespite comparable levels of hypertension treatment, African Americans in our HIV cohort were less likely to achieve blood pressure control. This may place them at increased risk for adverse outcomes that disproportionately impact HIV-infected patients, such as cardiovascular disease and chronic kidney disease, and thus attenuate the benefits conferred by combination antiretroviral therapy.

Indexed as

Antihypertensive AgentsBlood PressureCohort StudiesCross-Sectional StudiesFemaleHIV InfectionsHumansHypertensionMaleMiddle AgedPrevalenceRacial GroupsUnited StatesAntihypertensive Agents

Identifiers

PMID29596462
PMCPMC5875791
OpenAlexW2794481141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.