ArticlePloS one2018
The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Refining biomarker-based clustering of cardiovascular inflammatory phenotypes in HIV using Recursive Feature Addition: A comparative evaluation approach.PLoS computational biology · 2026Article
- Biomarkers of central and peripheral inflammation mediate the association between HIV and depressive symptoms.Translational psychiatry · 2023Article
- Equity in HIV mental health research: a call to action.Molecular psychiatry · 2022Article
- SARS-CoV-2 infection and coronavirus disease 2019 severity in persons with HIV on antiretroviral treatment.AIDS (London, England) · 2022Review
- Correlation between cerebrospinal fluid and plasma neurofilament light protein in treated HIV infection: results from the COBRA study.Journal of neurovirology · 2022Article
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- Article
- Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors.Frontiers in immunology · 2020Article
- Validation of a Novel Multivariate Method of Defining HIV-Associated Cognitive Impairment.Open forum infectious diseases · 2019Article
- Do people living with HIV experience greater age advancement than their HIV-negative counterparts?AIDS (London, England) · 2019Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging.
objectiveThe COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls.
methodsLongitudinal cohort study of HIV-positive subjects ≥45 years of age, with sustained HIV suppression on cART recruited from two large European HIV treatment centres and similarly-aged HIV-negative controls recruited from sexual health centres and targeted community groups. Both HIV-positive and HIV-negative subjects were assessed at study entry and again at follow-up after 2 years.
resultsOf the 134 HIV-positive individuals with a median (IQR) age of 56 (51, 62) years recruited, 93% were male, 88% of white ethnicity and 86% were men who have sex with men (MSM). Similarly, the 79 HIV-negative subjects had a median (IQR) age of 57 (52, 64) and 92% were male, 97% of white ethnicity and 80% were MSM.
conclusionsThe results from the COBRA study will be a significant resource to understand the link between HIV and AANCC and the pathogenic mechanisms underlying this link. COBRA will inform future development of novel prognostic tools for earlier diagnosis of AANCC and of novel interventions which, as an adjunct to cART, may prevent AANCC.
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