Evidence map›Paper›PMID 29596424›Full record

ArticlePLoS genetics2018

Germ cells in the teleost fish medaka have an inherent feminizing effect.

Toshiya Nishimura, Kazuki Yamada, Chika Fujimori, Mariko Kikuchi, Toshihiro Kawasaki, Kellee R Siegfried, Noriyoshi Sakai, Minoru Tanaka

Abstract read
In one paragraph

Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Article
  3. Differences in Early Development between Parental Species and Asexual Hybrids forms of European Spined Loaches (GenusSexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2026
    Article
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  16. Article
  17. Becoming female: Ovarian differentiation from an evolutionary perspective.Frontiers in cell and developmental biology · 2022
    Review
  18. Functional Modules in Gametogenesis.Frontiers in cell and developmental biology · 2022
    Article
  19. Review
  20. Sexual determination in zebrafish.Cellular and molecular life sciences : CMLS · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Toshiya NishimuraDivision of Biological Science, Nagoya University, Nagoya, Aichi, Japan.
Kazuki YamadaDivision of Biological Science, Nagoya University, Nagoya, Aichi, Japan.
Chika FujimoriDivision of Biological Science, Nagoya University, Nagoya, Aichi, Japan.
Mariko KikuchiDivision of Biological Science, Nagoya University, Nagoya, Aichi, Japan.
Toshihiro KawasakiGenetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka, Japan.
Kellee R SiegfriedBiology Department, University of Massachusetts Boston, Boston, Massachusetts, United States of America.
Noriyoshi SakaiGenetic Strains Research Center, National Institute of Genetics, Mishima, Shizuoka, Japan.
Minoru TanakaDivision of Biological Science, Nagoya University, Nagoya, Aichi, Japan.ORCID 0000-0001-9100-1487

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

author summaryGerm cells are the only cells that can transfer genetic materials to the next generation via the sperm or egg. However, recent analyses in teleosts revealed another essential role of germ cells: feminizing the gonads. In our study, medaka mutants in which gametogenesis was blocked at specific stages provides the novel view that the feminizing effect of germ cells occurs in parallel with other reproductive elements, such as meiosis, the sexual fate decision of germ cells, and gametogenesis. Germ cells in medaka may have a potential to feminize gonads at the moment they have developed.

Indexed as

FeminizationAnimalsCell LineageFemaleGametogenesisGerm CellsMaleMeiosisOryziasSex Differentiation

Identifiers

PMID29596424
PMCPMC5875746

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.