Trial reportThe Pediatric infectious disease journal2019
Dietary Supplementation With Medium-Chain Triglycerides Reduces Candida Gastrointestinal Colonization in Preterm Infants.
Trial report in The Pediatric infectious disease journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03630770 (Effect of Medium Chain Triglyceride Intake on Colonization of Preterm Infants With Candida), which is not on this map. Cited by 13 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Medium Chain Triglyceride Intake on Colonization of Preterm Infants With Candida
Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Enteral lipid supplements for the prevention and treatment of parenteral nutrition-associated liver disease in infants.The Cochrane database of systematic reviews · 2026Pooled it
- Eligibility Criteria and Representativeness of Randomized Clinical Trials That Include Infants Born Extremely Premature: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- High versus low medium chain triglyceride content of formula for promoting short-term growth of preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Nutritional interventions to reduce rates of infection, necrotizing enterocolitis and mortality in very preterm infants.Pediatric research · 2020Pooled it
- Trial
- Novel non-aqueous rotavirus vaccine: Formulated for thermostability and easy administration.Human vaccines & immunotherapeutics · 2026Article
- Review
- Gut bacteria: protective mediators, pathogenic contributors and novel therapeutic targets in Candida albicans infections.Gut pathogens · 2025Review
- The Effect of Medium-Chain Triglycerides Oil onAntibiotics (Basel, Switzerland) · 2024Article
- Role Medium-Chain Fatty Acids in the Lipid Metabolism of Infants.Frontiers in nutrition · 2022Review
- Review
- Breast Milk: A Source of Functional Compounds with Potential Application in Nutrition and Therapy.Nutrients · 2021Review
- Partridge and embryonated partridge egg as new preclinical models for candidiasis.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCandida is an important cause of infections in premature infants. Gastrointestinal colonization with Candida is a common site of entry for disseminated disease. The objective of this study was to determine whether a dietary supplement of medium-chain triglycerides (MCTs) reduces Candida colonization in preterm infants.
methodsPreterm infants with Candida colonization (n = 12) receiving enteral feedings of either infant formula (n = 5) or breast milk (n = 7) were randomized to MCT supplementation (n = 8) or no supplementation (n = 4). Daily stool samples were collected to determine fungal burden during a 3-week study period. Infants in the MCT group received supplementation during 1 week of the study period. The primary outcome was fungal burden during the supplementation period as compared with the periods before and after supplementation.
resultsSupplementation of MCT led to a marked increase in MCT intake relative to unsupplemented breast milk or formula as measured by capric acid content. In the treatment group, there was a significant reduction in fungal burden during the supplementation period as compared with the period before supplementation (rate ratio, 0.15; P = 0.02), with a significant increase after supplementation was stopped (rate ratio, 61; P < 0.001). Fungal burden in the control group did not show similar changes.
conclusionsDietary supplementation with MCT may be an effective method to reduce Candida colonization in preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.