ArticleAIDS (London, England)2018
Cardiac and inflammatory biomarkers in perinatally HIV-infected and HIV-exposed uninfected children.
Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adolescent Master Protocol
Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Longitudinal assessment of inflammatory biomarkers among youth with perinatal HIV infection and HIV exposure.AIDS (London, England) · 2026Article
- Left Ventricular Changes and Inflammatory Biomarkers in HIV-Exposed Uninfected Infants in Jos, Northcentral Nigeria.Pediatric cardiology · 2026Article
- Plasma Inflammatory Biomarkers Lack Strong Association With Cognitive Outcomes Among Young Adults With Perinatal HIV Exposure and/or Acquisition.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Cardiometabolic Health Burden in Pediatric HIV: Unmet Need in the Contemporary Antiretroviral Therapy Era.Cureus · 2025Review
- Bone Accrual Trajectories in Children and Adolescents With Perinatal HIV Infection.The Journal of clinical endocrinology and metabolism · 2025Article
- Relationship between brain structural network integrity and emotional symptoms in youth with perinatally-acquired HIV.Brain, behavior, and immunity · 2024Article
- Review
- Biomarkers of Tuberculous Meningitis and Pediatric Human Immunodeficiency Virus on the African Continent.Frontiers in neurology · 2022Review
- Application of Combined Detection of Echocardiography and Serum NT-ProBNP in the Diagnosis of Diastolic Heart Failure and Its Effect on Left Ventricular Morphology and Diastolic Function.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Cardiometabolic Complications in Youth With Perinatally Acquired HIV in the Era of Antiretroviral Therapy.Current HIV/AIDS reports · 2021Review
- Components of metabolic syndrome associated with lower neurocognitive performance in youth with perinatally acquired HIV and youth who are HIV-exposed uninfected.Journal of neurovirology · 2021Observational
- Adolescents and young adults with early acquired HIV infection in the united states: unique challenges in treatment and secondary prevention.Expert review of anti-infective therapy · 2021Review
- Altered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in Tanzania.Frontiers in cellular and infection microbiology · 2021Article
- Rethinking COVID-19 in children: Lessons learned from pediatric viral and inflammatory cardiovascular diseases.Progress in pediatric cardiology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
objectivesTo compare distributions of serum cardiac and inflammatory biomarkers between perinatally HIV-infected (PHIV) and perinatally HIV-exposed uninfected (PHEU) children, to evaluate their associations with echocardiographic measures, and among PHIV youth, with antiretroviral therapy (ART) and HIV disease severity measures.
designCross-sectional analysis of temporally paired serum samples for biomarkers and echocardiograms in a prospective multicenter cohort study of PHIV and PHEU youth.
methodsSerum samples were analyzed among 402 youth in the PHACS Adolescent Master Protocol (AMP) for high-sensitivity cardiac troponin-T (hs-cTnT, a cardiomyocyte injury marker), N-terminal-pro-brain natriuretic peptide (NT-proBNP, a myocardial stress marker), and inflammatory markers [high-sensitivity C-reactive protein, interleukin (IL)-1, IL-6, IL-8, IL-10, IL-18, tumor necrosis factor-α (TNF-α), and soluble TNF receptor II (sTNF-RII)]. Echocardiograms were centrally measured and parameters converted to z cores to account for differences in age and body size.
resultsCompared with PHEU (N = 156), PHIV youth (N = 246) more often had detectable hs-cTnT and higher levels of sTNF-RII and IL-18. Higher inflammatory biomarkers were generally associated with higher left ventricular (LV) wall stress and lower LV function and LV mass in the two groups. Among PHIV youth, the biomarkers were more strongly associated with current rather than historical immunologic and virologic status.
conclusionPHEU and PHIV have modest, significant differences in serum levels of specific inflammatory and active myocardial injury biomarkers. Higher biomarker levels were associated with lower LV mass and shifts in LV structure. Further study is warranted on the longitudinal role of cardiac and inflammatory biomarkers for targeting interventions among PHIV and PHEU youth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.