Evidence map›Paper›PMID 29596047›Full record

ArticleeLife2018

Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility.

Valerie A Larson, Yevgeniya Mironova, Kimberly G Vanderpool, Ari Waisman, John E Rash, Amit Agarwal, Dwight E Bergles

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Activation of Kir4.1 Channels by 2-D08 Promotes Myelin Repair in Multiple Sclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Morphology of Oligodendroglial Cells.Advances in neurobiology · 2025
    Review
  20. Channels and Transporters in Ischemic Brain Edema.Journal of inflammation research · 2025
    Review

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Valerie A LarsonThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0003-0778-0305
Yevgeniya MironovaThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Kimberly G VanderpoolDepartment of Biomedical Sciences, Colorado State University, Fort Collins, United States.
Ari WaismanInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
John E RashDepartment of Biomedical Sciences, Colorado State University, Fort Collins, United States.
Amit AgarwalThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0001-7948-4498
Dwight E BerglesThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID http://orcid.org/0000-0002-7133-7378
Johns Hopkins University · USColorado State University · USJohannes Gutenberg University Mainz · DE

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
UCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2M
Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
The Gateway Hypothesis: A new framework for unraveling diverse leukodystrophiesR01NS080153 · NINDS · COLORADO STATE UNIVERSITY · PI RASH, JOHN E · 2013 to 2017
$2.0M
Neuronal Regulation of NG2 CellsR01NS051509 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BERGLES, DWIGHT E · 2006 to 2010
$1.8M
NIGMS NIH HHS T32 GM007309NIH HHS NS050274NIH HHS NS051509NIH HHS NS080153NIH HHS U42 OD012210NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS051509NINDS NIH HHS R01 NS080153
6 · The paper itself

Abstract

The inwardly rectifying K

Indexed as

AnimalsGene DeletionHomeostasisKcnj10 ChannelMiceMice, KnockoutMice, TransgenicMyelin SheathOligodendrogliaPotassiumPotassium Channels, Inwardly RectifyingSeizuresWhite MatterKcnj10 ChannelPotassiumPotassium Channels, Inwardly RectifyingepilepsyKir4.1mousemyelinneuroscienceoligodendrocytepotassiumseizure

Identifiers

PMID29596047
PMCPMC5903864
OpenAlexW2795075974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.