ArticlePhysiological reports2018
Capturing the multifactorial nature of ARDS - "Two-hit" approach to model murine acute lung injury.
Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Targeting NETosis in the Lung: Respiratory Delivery of Neutrophil-Specific NEBP-Liposomes for Enhanced Therapy of Acute Lung Injury.Molecular pharmaceutics · 2026Article
- Animal models of critical illness in the Asia-Pacific region: current practices, shared challenges, and future directions.Intensive care medicine experimental · 2026Review
- Experimental animal models of acute respiratory distress syndrome: one-hit and two-hit establishment application.Frontiers in immunology · 2025Review
- Lung uptake of two SPECT markers identifies sensitivity to hyperoxia-induced acute respiratory distress syndrome in rats.Frontiers in physiology · 2025Article
- CMTM3 regulates vascular endothelial cell dysfunction by influencing pulmonary vascular endothelial permeability and inflammation in ARDS.Frontiers in immunology · 2025Article
- Associated effects of lipopolysaccharide, oleic acid, and lung injury ventilator-induced in developing a model of moderate acute respiratory distress syndrome in New Zealand white rabbits.Frontiers in veterinary science · 2025Article
- Effects of pressure-controlled ventilation-volume guaranteed on children undergoing thoracic surgery: a prospective, randomized controlled trial.Frontiers in medicine · 2025Article
- Lactate produced by alveolar type II cells suppresses inflammatory alveolar macrophages in acute lung injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Truncated oxidized phospholipids exacerbate endothelial dysfunction and lung injury caused by bacterial pathogens.Cellular signalling · 2023Article
- Risk factors for ventilator-induced-lung injury develop three to five times faster after a single episode of lung injury.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023Article
- Synergistic Effects of Resistive Breathing on Endotoxin-Induced Lung Injury in Mice.International journal of chronic obstructive pulmonary disease · 2023Article
- Efficacy of surfactant therapy of ARDS induced by hydrochloric acid aspiration followed by ventilator-induced lung injury - an animal study.Physiological research · 2022Article
- HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury.JCI insight · 2022Article
- Gastric Aspiration and Ventilator-Induced Model of Acute Respiratory Distress Syndrome in Swine.The Journal of surgical research · 2022Article
- Comparison of Local and Systemic Inflammation During Invasive Versus Noninvasive Ventilation in Rats.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022Article
- Lipopolysaccharide-induced murine lung injury results in long-term pulmonary changes and downregulation of angiogenic pathways.Scientific reports · 2022Article
- Antioxidants as Therapeutic Agents in Acute Respiratory Distress Syndrome (ARDS) Treatment-From Mice to Men.Biomedicines · 2022Review
- DerinatFrontiers in pharmacology · 2022Article
- Understanding the role of neutrophils in acute respiratory distress syndrome.Biomedical journal · 2021Review
- A Peptide Inhibitor of Peroxiredoxin 6 Phospholipase AAntioxidants (Basel, Switzerland) · 2021Article
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Authors and funding
9 authors.
Funding
Abstract
Severe acute respiratory distress syndrome (ARDS) presents typically with an initializing event, followed by the need for mechanical ventilation. Most animal models of ALI are limited by the fact that they focus on a singular cause of acute lung injury (ALI) and therefore fail to mimic the complex, multifactorial pathobiology of ARDS. To better capture this scenario, we provide a comprehensive characterization of models of ALI combining two injuries: intra tracheal (i.t.) instillation of LPS or hypochloric acid (HCl) followed by ventilator-induced lung injury (VILI). We hypothesized, that mice pretreated with LPS or HCl prior to VILI and thus receiving a ("two-hit injury") will sustain a superadditive lung injury when compared to VILI. Mice were allocated to following treatment groups: control with i.t. NaCl, ventilation with low peak inspiratory pressure (PIP), i.t. HCl, i.t. LPS, VILI (high PIP), HCl i.t. followed by VILI and LPS i.t. followed by VILI. Severity of injury was determined by protein content and MPO activity in bronchoalveolar lavage (BAL), the expression of inflammatory cytokines and histopathology. Mice subjected to VILI after HCl or LPS instillation displayed augmented lung injury, compared to singular lung injury. However, mice that received i.t. LPS prior to VILI showed significantly increased inflammatory lung injury compared to animals that underwent i.t. HCl followed by VILI. The two-hit lung injury models described, resulting in additive but differential acute lung injury recaptures the clinical relevant multifactorial etiology of ALI and could be a valuable tool in translational research.
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