ArticlePhysiological reports2018
Impaired autonomic function in adolescents born preterm.
Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005289 (Risk Factors in Bronchopulmonary Dysplasia), which is not on this map. Cited by 38 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Risk Factors in Bronchopulmonary Dysplasia (Newborn Lung Project)
Who cites it
38 citing papers in PubMed, 6 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Heart rate variability after hospital discharge in perinatal risk populations: a systematic review and meta-analysis.Pediatric research · 2026Pooled it
- Effect of Non-Pharmacological Methods in the Reduction of Neonatal Pain: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- A systematic review to investigate whether birth weight affects the autonomic nervous system in adulthood.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Pooled it
- Parent-Infant Skin-to-Skin Contact and Stress Regulation: A Systematic Review of the Literature.International journal of environmental research and public health · 2021Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Autonomic dysfunction and sudden death in patients with Rett syndrome: a systematic reviewJournal of psychiatry & neuroscience : JPN · 2020Pooled it
- Regulation of Stress Physiology Across Social Contexts in Preterm-Born Preschoolers.Psychophysiology · 2026Article
- Preterm birth and birth weight extremes are associated with periodontal disease and tooth loss in the ARIC study.Scientific reports · 2026Article
- Prenatal factors shaping adolescent cardiovascular function and cardiometabolic risk trajectories.Frontiers in pediatrics · 2026Review
- Cardiac autonomic function in adults born preterm with very low birth weight in mid-adulthood-A two-country birth cohort study.Physiological reports · 2025Article
- Development of Respiratory Sinus Arrhythmia in Young Infants With Autism Spectrum Disorder, Preterm Birth, and Typical Development.Autism research : official journal of the International Society for Autism Research · 2025Article
- Preterm Infant's Heart Rate Variability Near Birth Predicts Autonomic Symptoms at Age 3 to 5 Years.AJP reports · 2024Article
- Impact of prematurity on lifelong cardiovascular health: structural and functional considerations.NPJ cardiovascular health · 2024Review
- Heart Rate and Heart Rate Variability in Healthy Preterm-Born Young Adults and Association with Vitamin D: A Wearable Device Assessment.Journal of clinical medicine · 2023Article
- Consequences of Preterm Birth: Knowns, Unknowns, and Barriers to Advancing Cardiopulmonary Health.Integrative and comparative biology · 2023Article
- Preterm-born individuals: a vulnerable population at risk of cardiovascular morbidity and mortality during thermal extremes?Experimental physiology · 2023Review
- Fear conditioning is preserved in very preterm-born young adults despite increased anxiety levels.Scientific reports · 2023Article
- Association of Gestation and Fetal Growth Restriction on Cardiovascular Health in Preterm-Born Children.The Journal of pediatrics · 2023Article
- Article
- Understanding the preterm human heart: What do we know so far?Anatomical record (Hoboken, N.J. : 2007) · 2022Review
Corrections and comments
- Commented on by
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Preterm birth temporarily disrupts autonomic nervous system (ANS) development, and the long-term impacts of disrupted fetal development are unclear in children. Abnormal cardiac ANS function is associated with worse health outcomes, and has been identified as a risk factor for cardiovascular disease. We used heart rate variability (HRV) in the time domain (standard deviation of RR intervals, SDRR; and root means squared of successive differences, RMSSD) and frequency domain (high frequency, HF; and low frequency, LF) at rest, as well as heart rate recovery (HRR) following maximal exercise, to assess autonomic function in adolescent children born preterm. Adolescents born preterm (less than 36 weeks gestation at birth) in 2003 and 2004 and healthy age-matched full-term controls participated. Wilcoxon Rank Sum tests were used to compare variables between control and preterm groups. Twenty-one adolescents born preterm and 20 term-born controls enrolled in the study. Preterm-born subjects had lower time-domain HRV, including SDRR (69.1 ± 33.8 vs. 110.1 ± 33.0 msec, respectively, P = 0.008) and RMSSD (58.8 ± 38.2 vs. 101.5 ± 36.2 msec, respectively, P = 0.012), with higher LF variability in preterm subjects. HRR after maximal exercise was slower in preterm-born subjects at 1 min (30 ± 12 vs. 39 ± 9 bpm, respectively, P = 0.013) and 2 min (52 ± 10 vs. 60 ± 10 bpm, respectively, P = 0.016). This study is the first report of autonomic dysfunction in adolescents born premature. Given prior association of impaired HRV with adult cardiovascular disease, additional investigations into the mechanisms of autonomic dysfunction in this population are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.