SynthesisMedicine2018
Assessment of the periodontal health status in patients undergoing orthodontic treatment with fixed appliances and Invisalign system: A meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical guidelines and planning for orthodontic-surgical treatment using clear aligners.Dental press journal of orthodontics · 2025Guideline
- Efficacy of adjunctive systemic or local antibiotic therapy in peri-implantitis: a systematic review and meta-analysis of randomized controlled clinical trials.Journal of Zhejiang University. Science. B · 2024Pooled it
- White spot lesions, plaque accumulation and salivary caries-associated bacteria in clear aligners compared to fixed orthodontic treatment. A systematic review and meta- analysis.BMC oral health · 2023Pooled it
- Effectiveness of different intrusion protocols with clear aligner for maxillary anterior teeth in periodontitis: a finite element analysis.BMC oral health · 2026Article
- Patients' needs, expectations & concerns regarding clear aligner treatment.Clinical oral investigations · 2026Article
- Dietary changes in patients with clear aligners compared with fixed orthodontic appliances during the early stages of orthodontic treatment: A systematic review.Korean journal of orthodontics · 2026Article
- [Follow-up study evaluating morphological changes in alveolar bone in the maxillary anterior region after extraction retraction in adult patients treated with clear aligners on the basis of cone beam computed tomography data].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Article
- Review
- Evaluating the Impact of Clear Dental Aligners on Dental and Periodontal Conditions, Oral Microbial Patterns, and the Immune System.Advances in experimental medicine and biology · 2026Review
- Perception and satisfaction in patients using clear aligners versus fixed orthodontic appliances.Bioinformation · 2026Article
- Iterative finite element analysis of clear aligner-induced bodily canine movement under alveolar bone loss conditions.Korean journal of orthodontics · 2025Article
- Incidence and risk factors of alveolar bone dehiscences and fenestrations after clear aligner therapy with Class II elastics: a retrospective study.BMC oral health · 2025Article
- Oral health in adolescents: periodontal inflammatory biomarkers during orthodontic clear aligner therapy.Clinical oral investigations · 2025Article
- Article
- A comparison of the alterations of oral microbiome with fixed orthodontic therapy and clear aligners: a systematic review.Journal of oral microbiology · 2025Review
- Longitudinal Microbiome Changes in Supragingival Biofilm Transcriptomes Induced by Orthodontics.JDR clinical and translational research · 2024Article
- Effect of attachment flash on clear aligner force delivery: an in vitro study.BMC oral health · 2024Article
- Association between Gingival Phenotype and Periodontal Disease Severity-A Comparative Longitudinal Study among Patients Undergoing Fixed Orthodontic Therapy and Invisalign Treatment.Healthcare (Basel, Switzerland) · 2024Article
- Comparative characterization of supragingival plaque microbiomes in malocclusion adult female patients undergoing orthodontic treatment with removable aligners or fixed appliances: a descriptive cross-sectional study.Frontiers in cellular and infection microbiology · 2024Article
- Effects of the Saliva of Patients Undergoing Orthodontic Treatment with Invisalign and Brackets on Human Gingival Fibroblasts and Oral Epithelial Cells.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAt present, many scholars have studied the periodontal health status of patients undergoing orthodontic treatment with fixed appliances and invisalign. However, those results are inconsistent. Therefore, we conducted this meta-analysis, and then provide reference for clinical treatment.
methodsMost databases, such as the Cochrane Library, EMBASE, PubMed, Medline, Chinese Biomedical Literature Database, CNKI, and Wan Fang Data were retrieved for related articles from the establishment of the database to October 2017. Meanwhile, we also searched the references of the related literatures manually, in order to increase the included literatures. Two researchers screened the related literatures according to the inclusion criteria and exclusion criteria. Stata 12.0 software was used for data analysis, and results are estimated by odds ratio (OR) and 95% confidence interval (CI).
resultsFinally, 7 articles, including 368 patients, were included into our meta-analysis. Meta-analysis results showed that there was no statistically significant difference of gingival index (GI) and sulcus probing depth (SPD) status between the invisalign group and the control group, including at 1, 3, and 6 months (all P > .05). When compared with the control group, the invisalign group presented a lower plaque index (PLI) and sulcus bleeding index (SBI) status at 1 month (OR = -0.53, 95% CI: -0.89 to -0.18; OR = -0.44, 95% CI: -0.70 to -0.19, respectively), 3 months (OR = -0.69, 95% CI: -1.12 to -0.27; OR = -0.49, 95% CI: -0.93 to -0.05, respectively), and 6 months (OR = -0.91, 95% CI: -1.47 to -0.35; OR = -0.40, 95% CI: -0.63 to -0.07, respectively). Subgroup analysis showed that the SPD status was lower in the invisalign group at 6 months when measured the teeth using Ramfjord index (OR = -0.74, 95% CI: -1.35 to -0.12). However, there was no statistically significant difference between the 2 groups when using other measure methods (OR = 0.12, 95% CI: -0.26 to 0.17).
conclusionOur meta-analysis suggests that comparing with the traditional fixed appliances, patients treated with invisalign have a better periodontal health. However, more studies are needed to confirm this conclusion in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.