Evidence map›Paper›PMID 29595667›Full record

ArticleMedicine2018

Association between BACE1 gene polymorphisms and focal seizures in a Chinese Han population.

Guangsheng Yang, Haidong Wang, Xin He, Pengfei Xu, Ruili Dang, Qingyan Feng, Pei Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 72% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Guangsheng YangPhase I Clinical Research Center, Department of Pharmacy, The First People's Hospital of Lianyungang, The Affiliated Hospital of Kangda College of Nanjing Medical University, Jiangsu, Lianyungang Institute of Clinical Pharmacy and Pharmacology, Jining First People's Hospital, Jining Medical University, Jining Department of Neurology, Jining First People's Hospital, Jining Medical University, Jining Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha, China.
Haidong Wang
Xin He
Pengfei Xu
Ruili Dang
Qingyan Feng
Pei Jiang
Jining Medical University · CNKangda College of Nanjing Medical UniversityJining First People's Hospital · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBeta-secretase 1 (BACE1) is attracting increasing attention for its vital role in pathogenesis of many neuropsychiatric disorders and many studies also have indicated BACE1 as a possible risk factor for seizures, but not any studies have reported association between BACE1 gene polymorphisms and seizures. Therefore, we investigated the possible association between focal seizures and BACE1 gene polymorphisms in the present study.

methodsA total of 162 patients and 211 health controls were enrolled in this study and polymorphisms of BACE1 gene were detected using polymerase chain reaction (PCR)-ligase detection reaction method.

resultsThe frequency of genotype AT for BACE1 rs535860 (A>T) was significantly higher (24.1%) in patients compared to controls (14.7%) (OR = 1.836, 95% CI = 1.086-3.102, P = .023). Intriguingly, we only found the significant difference of BACE1 SNP genotype and allele frequency among males but not females. However, no statistically significant results were presented for the genotype distributions of rs525493 (G>T) and rs638405(C>G) polymorphisms between patients and controls.

conclusionOur study demonstrated there may exist an association between BACE1 rs535860 (A>T) polymorphism and focal seizures in Chinese Han males.

Indexed as

AdolescentAmyloid Precursor Protein SecretasesAsian PeopleAspartic Acid EndopeptidasesChildChild, PreschoolChinaFemaleGene FrequencyHumansInfantMalePolymerase Chain ReactionPolymorphism, Single NucleotideRisk FactorsSeizuresAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, human

Identifiers

PMID29595667
PMCPMC5895388
OpenAlexW2980334622

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.