ArticleeLife2018
Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Elastic Cytomatrix Dynamics Influences Metabolic Rate and Tumor Microenvironment Formation.Cancers · 2025Review
- Cell jamming transitions can affect regulatory protein gradients and prime evolutionary divergence.Journal of the Royal Society, Interface · 2025Article
- A growing problem: The many unsolved mysteries of cell growth.Molecular biology of the cell · 2025Review
- A generalized adder for cell size homeostasis: Effects on stochastic clonal proliferation.Biophysical journal · 2025Article
- Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis.eLife · 2025Article
- Cross-species single-nucleus analysis reveals the potential role of whole-genome duplication in the evolution of maize flower development.BMC genomics · 2025Article
- Eukaryotic cell size regulation and its implications for cellular function and dysfunction.Physiological reviews · 2024Review
- A GeneralizedbioRxiv : the preprint server for biology · 2024Article
- The Role of Intracellular Potassium in Cell Quiescence, Proliferation, and Death.International journal of molecular sciences · 2024Review
- Cell size homeostasis is tightly controlled throughout the cell cycle.PLoS biology · 2024Article
- The role ofJournal of pharmaceutical analysis · 2023Review
- Novel determinants of cell size homeostasis in the opportunistic yeast Candida albicans.Current genetics · 2023Article
- Editorial: Cell size regulation: molecular mechanisms and physiological importance.Frontiers in cell and developmental biology · 2023Article
- Cell growth and the cell cycle: New insights about persistent questions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Review
- Endothelial cell cycle state determines propensity for arterial-venous fate.Nature communications · 2022Article
- The histone methyltransferase SETD2 negatively regulates cell size.Journal of cell science · 2022Article
- Virtual screening for small-molecule pathway regulators by image-profile matching.Cell systems · 2022Article
- Regulation of the p38-MAPK pathway by hyperosmolarity and by WNK kinases.Scientific reports · 2022Article
- Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC.BMC biology · 2022Article
- Scaling of biosynthesis and metabolism with cell size.Molecular biology of the cell · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Animal cells within a tissue typically display a striking regularity in their size. To date, the molecular mechanisms that control this uniformity are still unknown. We have previously shown that size uniformity in animal cells is promoted, in part, by size-dependent regulation of G1 length. To identify the molecular mechanisms underlying this process, we performed a large-scale small molecule screen and found that the p38 MAPK pathway is involved in coordinating cell size and cell cycle progression. Small cells display higher p38 activity and spend more time in G1 than larger cells. Inhibition of p38 MAPK leads to loss of the compensatory G1 length extension in small cells, resulting in faster proliferation, smaller cell size and increased size heterogeneity. We propose a model wherein the p38 pathway responds to changes in cell size and regulates G1 exit accordingly, to increase cell size uniformity.
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Registered trials
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