Evidence map›Paper›PMID 29594994›Full record

ArticleHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology2018

[K (lysine) acetyltransferase 2A affects the osteogenic differentiation of periodontal ligament stem cells through the canonical Wnt pathway].

Guo Wucheng, Cheng Jieli, Yang Zhengyi, Zhang Yi, He Enliang, Qian Jun, Song Jingjing, Sun Jin, Yuan Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Guo WuchengDept. of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Cheng JieliDept. of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Yang ZhengyiDept. of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Zhang YiDept. of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
He EnliangDept. of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Qian JunDept. of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Song JingjingDept. of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Sun JinStomatological Disease Center, Shenzhen Maternal and Child Health Care Hospital, Southern Medical University, Shenzhen 518048, China.
Yuan LinDept. of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
First Affiliated Hospital of Guangzhou Medical University · CNShenzhen Maternity and Child Healthcare Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to investigate the mechanism of K (lysine) acetyltransferase 2A (KAT2A) regulation and control on the osteogenic differentiation of periodontal ligament stem cells (PDLSCs).

methodsThe expression levels of KAT2A in PDLSCs were compared from each generation of the normal (H-PDLSCs) and periodontitis tissues (P-PDLSCs). The influences of KAT2A gene interference on the osteogenic differentiation of PDLSCs were also detected. In addition, the influences of the KAT2A gene interference to the canonical Wnt pathway and ligands were detected. The upstream and down-stream relationships between KAT2A and canonical Wnt pathway were also determined.

resultsThe decreased expression of KAT2A in PDLSCs from the inflammatory tissue in each generation was compared with that in PDLSCs from the healthy tissue, and the difference was statistically significant (P<0.05). When the KAT2A gene was disrupted, the osteogenesis ability of PDLSC was declined, and the difference was statistically significant (P<0.05). The canonical Wnt pathway was activated, and the antagonist Dickkopf-1 (DKK-1) was reduced. After the DKK-1 addition, the osteogenic differentiation of the disturbed PDLSCs was recovered, and KAT2A was unaffected.

conclusionsThe KAT2A expression in PDLSCs was decreased because of perio-dontitis. The classical Wnt pathway was activated to inhibit the osteogenic differentiation of the cells.

Indexed as

Histone AcetyltransferasesOsteogenesisPeriodontal LigamentPeriodontitisWnt Signaling PathwayAcetyltransferasesCell DifferentiationCells, CulturedHumansLysinep300-CBP-Associated FactorStem CellsAcetyltransferasesHistone AcetyltransferasesKAT2A protein, humanLysinep300-CBP-Associated Factoracetyltransferaseclassical Wnt pathwayosteogenic differentiationperiodontal ligament stem cellsperiodontitis

Identifiers

PMID29594994
PMCPMC7030166
OpenAlexW2992255792

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.