Evidence map›Paper›PMID 29594970›Full record

ArticleDigestive diseases and sciences2018

Lower Sustained Diphtheria and Pertussis Antibody Concentrations in Inflammatory Bowel Disease Patients.

Freddy Caldera, Sumona Saha, Arnold Wald, Christine A Garmoe, Sue McCrone, Bryant Megna, Dana Ley, Mark Reichelderfer, Mary S Hayney

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02434133 (Cross Sectional Study of Vaccine Antibody Response in Inflammatory Bowel Disease Patients), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02434133 completednot on this map

Cross Sectional Study of Vaccine Antibody Response in Inflammatory Bowel Disease Patients

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2015 to 2017Enrolled110ConditionsInflammatory Bowel Disease (IBD)ArmsBlood Draw/Data Collection
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. A comprehensive review of vaccination in patients with inflammatory bowel diseases:  An Indian perspective.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020
    Review
  8. Review
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Update on Vaccinating the Patient With Inflammatory Bowel Disease.Current treatment options in gastroenterology · 2018
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Freddy CalderaDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, Madison, WI, 53705-2281, USA. fcaldera@medicine.wisc.edu.
Sumona SahaDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, Madison, WI, 53705-2281, USA.
Arnold WaldDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, Madison, WI, 53705-2281, USA.
Christine A GarmoeSchool of Pharmacy, University of Wisconsin, 777 Highland Ave., Madison, WI, 53705, USA.
Sue McCroneSchool of Pharmacy, University of Wisconsin, 777 Highland Ave., Madison, WI, 53705, USA.
Bryant MegnaSchool of Medicine and Public Health, University of Wisconsin, 750 Highland Ave., Madison, WI, 53705, USA.
Dana LeySchool of Medicine and Public Health, University of Wisconsin, 750 Highland Ave., Madison, WI, 53705, USA.
Mark ReichelderferDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, 1685 Highland Avenue, Madison, WI, 53705-2281, USA.
Mary S HayneySchool of Pharmacy, University of Wisconsin, 777 Highland Ave., Madison, WI, 53705, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with inflammatory bowel disease (IBD) are often immunosuppressed, and those patients receiving anti-tumor necrosis factor α (TNF) therapy can have lower antibody responses to vaccines. Pertussis cases are at their highest levels in the post-vaccine era. There is little data regarding responses to the Tdap (tetanus, diphtheria, and acellular pertussis) vaccine in IBD patients.

aimsThe aim of this study was to compare sustained vaccine-induced Tdap antibody concentrations in a cohort of IBD patients stratified by medication regimens with healthy controls (HC) who had received an adult Tdap booster.

methodsWe performed a cross-sectional study evaluating antibody responses to Tdap vaccine among IBD patients compared to HC. Our study consisted of three patient groups: adults with IBD stratified by maintenance medication regimen: (1) thiopurine monotherapy; (2) anti-TNF monotherapy; and (3) combination therapy (anti-TNF and immunomodulator (thiopurine or methotrexate)).

resultsNinety IBD patients and 20 HC participated. Pertussis pertactin antibody concentrations were significantly lower in IBD patients (p = 0.021) compared to HC, and those on anti-TNF agents (monotherapy or combination) had lower antibody concentrations compared to those on thiopurine monotherapy (p = 0.028). Diphtheria antibody concentrations were also lower in IBD patients (p < 0.001), and those on anti-TNF agents (monotherapy or combination) had lower antibody concentrations compared to the thiopurine monotherapy group (p < 0.001).

conclusionIBD patients on anti-TNF agents had lower antibody concentrations to diphtheria and pertussis. These findings suggest a need for different Tdap booster schedules for IBD patients on anti-TNF therapy. Clinical Trials Registry NCT02434133.

Indexed as

Immunocompromised HostImmunogenicity, VaccineAdultAntibodies, BacterialBiomarkersBordetella pertussisCase-Control StudiesCross-Sectional StudiesDiphtheriaDiphtheria-Tetanus-acellular Pertussis VaccinesDrug Therapy, CombinationFemaleHumansImmunization, SecondaryImmunosuppressive AgentsInflammatory Bowel DiseasesAntibodies, BacterialBiomarkersDiphtheria-Tetanus-acellular Pertussis VaccinesImmunosuppressive AgentsTumor Necrosis Factor-alphaDiphtheriaImmunizationInflammatory bowel diseasePertussisTetanus

Identifiers

PMID29594970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.