ArticleDigestive diseases and sciences2018
Fecal Microbiome Among Nursing Home Residents with Advanced Dementia and Clostridium difficile.
Article in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Age-Related Cognitive Decline, Focus on Microbiome: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review.Clinical interventions in aging · 2018Pooled it
- Screening and Characterization ofAntioxidants (Basel, Switzerland) · 2023Article
- Gut Microbiota Composition Associated withPathogens (Basel, Switzerland) · 2022Review
- Preventive Effects ofFrontiers in microbiology · 2021Article
- DietaryFrontiers in veterinary science · 2021Article
- Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study.BMC geriatrics · 2020Article
- Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis.Mediators of inflammation · 2020Article
- Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer's Disease.BioMed research international · 2020Article
- Exercise, the Gut Microbiome, and Frailty.Annals of geriatric medicine and research · 2019Review
- Gut Microbiota Disorder, Gut Epithelial and Blood-Brain Barrier Dysfunctions in Etiopathogenesis of Dementia: Molecular Mechanisms and Signaling Pathways.Neuromolecular medicine · 2019Review
- Current Perspectives and Mechanisms of Relationship between Intestinal Microbiota Dysfunction and Dementia: A Review.Dementia and geriatric cognitive disorders extraReview
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND/
objectivesPatients colonized with toxinogenic strains of Clostridium difficile have an increased risk of subsequent infection. Given the potential role of the gut microbiome in increasing the risk of C. difficile colonization, we assessed the diversity and composition of the gut microbiota among long-term care facility (LTCF) residents with advanced dementia colonized with C. difficile.
designRetrospective analysis of rectal samples collected during a prospective observational study.
settingThirty-five nursing homes in Boston, Massachusetts.
participantsEighty-seven LTCF residents with advanced dementia. MEASUREMENTS: Operational taxonomic units were identified using 16S rRNA sequencing. Samples positive for C. difficile were matched to negative controls in a 1:3 ratio and assessed for differences in alpha diversity, beta diversity, and differentially abundant features.
resultsClostridium difficile sequence variants were identified among 7/87 (8.04%) residents. No patient had evidence of C. difficile infection. Demographic characteristics and antimicrobial exposure were similar between the seven cases and 21 controls. The overall biodiversity among cases and controls was reduced with a median Shannon index of 3.2 (interquartile range 2.7-3.9), with no statistically significant differences between groups. The bacterial community structure was significantly different among residents with C. difficile colonization versus those without and included a predominance of Akkermansia spp., Dermabacter spp., Romboutsia spp., Meiothermus spp., Peptoclostridium spp., and Ruminococcaceae UGC 009.
conclusionLTCF residents with advanced dementia have substantial dysbiosis of their gut microbiome. Specific taxa characterized C. difficile colonization status.
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Registered trials
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