ArticleOdontology2018
Cytotoxic and biological effects of bulk fill composites on rat cortical neuron cells.
Article in Odontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Evaluation of Wound Healing Potential of (5-formylfuran-2-yl)Methyl Benzoates byTurkish journal of pharmaceutical sciences · 2026Article
- Comparative assessment of antibacterial, antifungal, and cytotoxic activities of ceragenins CSA-44 and CSA-131 against endodontic pathogens.Folia microbiologica · 2025Article
- Effect of Rapid High-Intensity Light-Curing on Increasing Transdentinal Temperature and Cell Viability: An In Vitro Study.Polymers · 2024Article
- Assessing the impact of dental restorative materials on fibroblast cells: an immunohistochemical and ELISA analysis.Scientific reports · 2024Article
- Biocompatibility of different resin composites after polymerization with two light curing units: an immunohistochemical study.European oral research · 2024Article
- Evaluation of dental pulp stem cells response to flowable nano-hybrid dental composites: A comparative analysis.PloS one · 2024Article
- Biocompatibility of bulk-fill resins in vitro.Clinical oral investigations · 2023Article
- FePharmaceutics · 2023Article
- Mechanical Properties, Cytotoxicity, and Fluoride Ion Release Capacity of Bioactive Glass-Modified Methacrylate Resin Used in Three-Dimensional Printing Technology.Materials (Basel, Switzerland) · 2022Article
- Molecular Interactions between Saliva and Dental Composites Resins: A Way Forward.Materials (Basel, Switzerland) · 2021Review
- Cadmium sulfide-induced toxicity in the cortex and cerebellum:Toxicology reports · 2020Article
- Effect of preheating on the cytotoxicity of bulk-fill composite resins.Journal of dental research, dental clinics, dental prospects · 2020Article
- Depth-Dependent Cellular Response from Dental Bulk-Fill Resins in Human Dental Pulp Stem Cells.Stem cells international · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The aim of this study was to investigate potential cellular responses and biological effects of new generation dental composites on cortical neuron cells in two different exposure times. The study group included five different bulk-fill flow able composites; Surefil SDR Flow, X-tra Base Flow, Venus Bulk Flow, Filtek Bulk Flow and Tetric-Evo Flow. They were filled in Teflon molds (Height: 4 mm, Width: 6 mm) and irradiated for 20 s. Cortical neuron cells were inoculated into 24-well plates. After 80% of the wells were coated, the 3 µm membrane was inserted and dental filling materials were added. The experiment was continued for 24 and 72 h. Cell viability measured by MTT assay test, total antioxidant and total oxidant status were examined using real assay diagnostic kits. The patterns of cell death (apoptosis) were analyzed using annexin V-FITC staining with flow cytometry. Β-defensins were quantitatively assessed by RT-PCR. IL-6, IL-8 and IL-10 cytokines were measured from the supernatants. All composites significantly affected analyses parameters during the exposure durations. Our data provide evidence that all dental materials tested are cytotoxic in acute phase and these effects are induced cellular death after different exposure periods. Significant cytotoxicity was detected in TE, XB, SS, FBF and VBF groups at 24 and 72 h, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.