Evidence map›Paper›PMID 29594746›Full record

ReviewCurrent gastroenterology reports2018

Scaling Safe Access to Fecal Microbiota Transplantation: Past, Present, and Future.

Pratik Panchal, Shrish Budree, Alex Scheeler, Geraldine Medina, Monica Seng, Wing Fei Wong, Ryan Elliott, Ryan Eliott, Thomas Mitchell, Zain Kassam and 2 more

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Current gastroenterology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Microbiota-Based Live Biotherapeutic Products forInfection and drug resistance · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Regulation, risk and safety of Faecal Microbiota Transplant.Infection prevention in practice · 2020
    Review
  16. Article
  17. Article
  18. Treatment of Severe and Fulminnant Clostridioides difficile Infection.Current treatment options in gastroenterology · 2019
    Review
  19. Article
  20. Establishing a donor stool bank for faecal microbiota transplantation: methods and feasibility.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Pratik PanchalOpenBiome, Somerville, MA, USA. pratik@mail.harvard.edu.
Shrish BudreeOpenBiome, Somerville, MA, USA.
Alex ScheelerOpenBiome, Somerville, MA, USA.
Geraldine MedinaOpenBiome, Somerville, MA, USA.
Monica SengOpenBiome, Somerville, MA, USA.
Wing Fei WongOpenBiome, Somerville, MA, USA.
Ryan Elliott
Ryan Eliott *OpenBiome, Somerville, MA, USA.
Thomas MitchellFinch Therapeutics Group, Somerville, MA, USA.
Zain KassamFinch Therapeutics Group, Somerville, MA, USA.
Jessica R AllegrettiHarvard Medical School, Boston, MA, 02115, USA.
Majdi OsmanOpenBiome, Somerville, MA, USA.
OpenBiome · USFinch Therapeutics (United States) · USBrigham and Women's Hospital · USUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewUniversal stool banks (USBs) have emerged as a potential model for scaling access to fecal microbiota transplantation (FMT) for Clostridium difficile infection (CDI). In this review, we outline the historical barriers constraining access to FMT, the evidence on methods and outcomes of USBs, and potential future directions for expanding access. RECENT

findingsKey historical barriers to FMT access include regulatory uncertainty, operational complexity of sourcing screened donor material, and logistical challenges of delivering fresh treatment preparations. USBs have demonstrated that FMT can be delivered safely at scale by centralizing donor selection, material processing, and safety monitoring. More evidence is needed to optimize USB methods, including for donor screening, material processing, and novel delivery modalities. USBs have catalyzed broad access to FMT in North America and Europe. Future directions include developing evidence regarding oral preparations, harmonizing guidelines, disseminating best practice protocols, establishing long-term safety profiles, and expanding access to geographic areas of unmet need.

Indexed as

Clostridium InfectionsDonor SelectionFecal Microbiota TransplantationGastrointestinal MicrobiomeHealth Services AccessibilityHumansTissue BanksClostridium difficile infectionDonor screeningFecal microbiota transplantGeospatialMicrobiomeUniversal Stool Bank

Identifiers

PMID29594746
OpenAlexW2794631148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.