Evidence map›Paper›PMID 29594603›Full record

ArticleMikrochimica acta2018

On site visual detection of Porphyromonas gingivalis related periodontitis by using a magnetic-nanobead based assay for gingipains protease biomarkers.

Sahar Alhogail, Ghadeer A R Y Suaifan, Sergio Bizzarro, Wendy E Kaman, Floris J Bikker, Karina Weber, Dana Cialla-May, Jürgen Popp, Mohammed Zourob

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Iron Oxide-Based Magnetic Nanoparticles in Oral Infection Control.International journal of nanomedicine · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Implications ofFrontiers in cellular and infection microbiology · 2022
    Review
  11. Fast, Simple, and Highly Specific Molecular Detection ofFrontiers in cellular and infection microbiology · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Quercetin Inhibits Inflammatory Response Induced by LPSBioMed research international · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 4 countries.

Sahar AlhogailDepartment of Medical Technology, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Ghadeer A R Y SuaifanDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, 11942, Jordan.
Sergio BizzarroDepartment of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU UniversityAmsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
Wendy E KamanDepartment of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
Floris J BikkerDepartment of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
Karina WeberInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany.
Dana Cialla-MayInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany.
Jürgen PoppInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany.
Mohammed ZourobFaisal Specialist Hospital and Research Center, Zahrawi Street, Al Maather, Riyadh, 12713, Saudi Arabia. mzourob@alfaisal.edu.
InfectoGnostics Research Campus Jena · DEAcademic Center for Dentistry Amsterdam · NLAlfaisal University · SAErasmus MC · NLFriedrich Schiller University Jena · DEKing Saud University · SAUniversity of Amsterdam · NLUniversity of Jordan · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porphyromonas gingivalis (P. gingivalis) is a pathogen causing periodontitis. A rapid assay is described for the diagnosis of periodontal infections related to P. gingivalis. The method is making use of gingipains, a group of P. gingivalis specific proteases as a detection biomarker. Magnetic-nanobeads were labeled with gingipain-specific peptide substrates and immobilized on a gold biosensing platform via gold-thiol linkage. As a result of this, the color of the gold layer turns black. Upon cleavage of the immobilized substrates by gingipains, the magnetic-nanobeads-peptide fragments were attracted by a magnet so that the golden surface color becomes visible again. This assay is highly sensitive and specific. It is capable of detecting as little as 49 CFU·mL

Indexed as

Adhesins, BacterialBiomarkersColorimetryCysteine EndopeptidasesGingipain Cysteine EndopeptidasesHumansMagneticsNanoparticlesPeriodontitisPoint-of-Care SystemsPorphyromonas gingivalisSensitivity and SpecificityAdhesins, BacterialBiomarkersCysteine EndopeptidasesGingipain Cysteine EndopeptidasesBiosensorColorimetric assayDiagnosisGingivitisMagnetic nanoparticlesPeriodontal diseasesPoint of carePorphyromonas gingivalis

Identifiers

PMID29594603
OpenAlexW2786298302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.