ArticlePediatric nephrology (Berlin, Germany)2018
Urinary stone risk factors in the descendants of patients with kidney stone disease.
Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Elevation of urinary alpha-1-antitrypsin and transferrin excretion in children of patients with nephrolithiasis.Asian biomedicine : research, reviews and news · 2025Article
- Inverse association between prognostic nutritional index and kidney stone prevalence: A population-based study.PloS one · 2025Article
- Influence of Dietary Heritage in a Restricted Geographic Area and Role of Food Additives on Risk of Recurrent Kidney Stone.Nutrients · 2024Article
- Genetic mutation of SLC6A20 (c.1072T > C) in a family with nephrolithiasis: A case report.Open medicine (Warsaw, Poland) · 2023Article
- Urinary sulfated glycosaminoglycan insufficiency and chondroitin sulfate supplement in urolithiasis.PloS one · 2019Article
- Confounding risk factors and preventative measures driving nephrolithiasis global makeup.World journal of nephrology · 2018Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence has indicated that immediate family members of nephrolithiasis patients had high opportunity to develop stones. However, they are usually not regarded to be at risk, since it is unclear if there are any lithogenic abnormalities found in non-stone-forming nephrolithiasis relatives. Our aim was to investigate urinary metabolic abnormalities in the children of nephrolithiasis patients, compared with the general population.
methodsThe 24-h urinary metabolic profile was studied for 28 calcium oxalate nephrolithiasis patients (NL) and 46 of their descendants (ND), as well as 40 non-stone-forming volunteers (V) and 34 of their descendants (VD).
resultsThere was no difference between age, gender, and serum creatinine between NL vs. V (parental groups) and ND vs. VD (descendant groups). High urinary oxalate in nephrolithiasis and urinary calcium in their descendants was detected. In addition, an elevated urinary excretion rate of calcium, phosphate, protein, and albumin, along with low citrate excretion and high urinary supersaturation was observed in both the nephrolithiasis patients and their descendants. Approximate 17.8-24.4% of the nephrolithiasis descendants had a urinary supersaturation higher than the nephrolithiasis level, but none was found in VD group. The level of urinary supersaturation index was correlated with urinary protein and albumin excretion in nephrolithiasis family.
conclusionIt was demonstrated that nephrolithiasis offspring carried several urinary metabolic risks predisposing to stone formation which are similar to their parents, and about one in every five nephrolithiasis children had nephrolithiasis level urinary supersaturation.
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