Evidence map›Paper›PMID 29594502›Full record

ReviewPediatric cardiology2018

Fates Aligned: Origins and Mechanisms of Ventricular Conduction System and Ventricular Wall Development.

William R Goodyer, Sean M Wu

Abstract readReview
In one paragraph

Review in Pediatric cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Molecular Regulation of Cardiomyocyte Maturation.Current cardiology reports · 2025
    Review
  3. Article
  4. Article
  5. DbhNature communications · 2023
    Article
  6. Article
  7. Molecular and cellular basis of embryonic cardiac chamber maturation.Seminars in cell & developmental biology · 2021
    Review
  8. Zebrafish Models in Therapeutic Research of Cardiac Conduction Disease.Frontiers in cell and developmental biology · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

William R GoodyerCardiovascular Institute, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3252-1180
Sean M WuCardiovascular Institute, Stanford University, Stanford, CA, USA. smwu@stanford.edu.

Funding

Training in Myocardial Biology at Stanford (TIMBS)T32HL094274 · NHLBI · STANFORD UNIVERSITY · PI Euan A Ashley, Daniel Bernstein · 2010 to 2026
$5.0M
Enabling Technologies for Human-Machine Hybrid TissuesDP1LM012179 · NLM · STANFORD UNIVERSITY · PI WU, SEAN M · 2014 to 2018
$3.8M
American Heart Association Established Investigator Award 17EIA33410923NHLBI NIH HHS T32 HL094274NIH Office of the Director LM012179-03NLM NIH HHS DP1 LM012179Training Grant (T32) entitled Research Training in Myocardial Biology at Stanford NIH 2 T32 HL094274
6 · The paper itself

Abstract

The cardiac conduction system is a network of distinct cell types necessary for the coordinated contraction of the cardiac chambers. The distal portion, known as the ventricular conduction system, allows for the rapid transmission of impulses from the atrio-ventricular node to the ventricular myocardium and plays a central role in cardiac function as well as disease when perturbed. Notably, its patterning during embryogenesis is intimately linked to that of ventricular wall formation, including trabeculation and compaction. Here, we review our current understanding of the underlying mechanisms responsible for the development and maturation of these interdependent processes.

Indexed as

AnimalsAtrioventricular NodeCardiac Conduction System DiseaseHeart Conduction SystemHeart VentriclesHumansMiceMyocardiumTranscription FactorsTranscription FactorsArrhythmiaConduction systemMyocardial development

Identifiers

PMID29594502
PMCPMC6093793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.