ArticleMikrochimica acta2017
Fluorometric determination of lead(II) and mercury(II) based on their interaction with a complex formed between graphene oxide and a DNAzyme.
Article in Mikrochimica acta, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Combating small molecule environmental contaminants: detection and sequestration using functional nucleic acids.Chemical science · 2022Review
- Fluorescent Biosensors for the Detection of Viruses Using Graphene and Two-Dimensional Carbon Nanomaterials.Biosensors · 2022Review
- 2D Co-MOF nanosheet-based nanozyme with ultrahigh peroxidase catalytic activity for detection of biomolecules in human serum samples.Mikrochimica acta · 2021Article
- Highly active G-quadruplex/hemin DNAzyme for sensitive colorimetric determination of lead(II).Mikrochimica acta · 2019Article
- Electrochemical lead(II) biosensor by using an ion-dependent split DNAzyme and a template-free DNA extension reaction for signal amplification.Mikrochimica acta · 2019Article
- Probe computing model based on small molecular switch.BMC bioinformatics · 2019Article
- Two-dimensional nanomaterial based sensors for heavy metal ions.Mikrochimica acta · 2018Review
- Fluorometric determination of zinc(II) by using DNAzyme-modified magnetic microbeads.Mikrochimica acta · 2018Article
- Sensitive determination of Hg(II) based on a hybridization chain recycling amplification reaction and surface-enhanced Raman scattering on gold nanoparticles.Mikrochimica acta · 2018Article
- Colorimetric and visual detection of mercury(II) based on the suppression of the interaction of dithiothreitol with agar-stabilized silver-coated gold nanoparticles.Mikrochimica acta · 2018Article
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Authors and funding
3 authors.
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Abstract
The authors have designed a DNAzyme where graphene oxide (GO) interacts with the ssDNA stem loop region. The DNAzyme strand and substrate strand are hybridized and bind to the surface of GO which act as a signal reporter, while GO act as a strong quencher. The presence of Pb(II) ion disturbs the GO-DNAzyme complex and causes internal cleavage of the DNAzyme complex. On addition of Thioflavin T (ThT) as a quadruplex inducer, fluorescence intensity (best measured at excitation/emission peaks of 425/490 nm) is strongly enhanced. Subsequent addition of Hg(II) to ThT/G-quadruplex complex decreases fluorescence because the G-quadruplex is unwinding to form a T-Hg(II)-T dsDNA system. Therefore, the change in fluorescence intensity of ThT is directly correlated to the concentration of Pb(II) and Hg(II). As a result, the assay is highly selective and sensitive. The limits of detection are 96 pM for Pb(II) and 356 pM for Hg(II). Moreover, the method was applied to the detection of the two ions in spiked real samples and gave satisfactory results. Graphical abstract A label free sensitive and selective "on-off" fluorescent assay for detection of Pb(II) and Hg(II) based on graphene oxide -DNAzyme complex with fluorogenic dye thioflavin T. The limits of detection are 96 pM (Pb
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