ArticleInternational journal of colorectal disease2018
The prognostic implications of primary tumor location on recurrence in early-stage colorectal cancer with no associated risk factors.
Article in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Construction of a prognostic prediction model for colorectal cancer based on 5-year clinical follow-up data.Scientific reports · 2025Article
- Risk factors for recurrence in stage I colorectal cancer after curative resection: a systematic review and meta-analysis.Annals of surgical treatment and research · 2025Article
- Analysis of risk factors for postoperative recurrence of stage I colorectal cancer: a retrospective analysis of a large population.Frontiers in surgery · 2024Article
- Impact of general or regional anaesthesia on recurrence of colorectal cancer after surgery: Systematic review.Indian journal of anaesthesia · 2023Article
- Risk factors of recurrence in TNM stage I colorectal cancer.Annals of surgical treatment and research · 2023Article
- The presence of poorly differentiated clusters predicts survival in stage II colorectal cancer.Virchows Archiv : an international journal of pathology · 2021Article
- Proposal for a post-operative surveillance strategy for stage I colorectal cancer patients based on a novel recurrence risk stratification: a multicenter retrospective study.International journal of colorectal disease · 2021Article
- Recurrence, death risk, and related factors in patients with stage 0 colorectal cancer: A nationwide population-based study.Medicine · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecently, several reports have suggested that tumor location serves as a prognostic biomarker in advanced colorectal cancer. However, the prognostic implication of tumor location in patients with early-stage colorectal cancer remains unclear. This study was aimed to examine the prognostic implication of tumor location in patients with early-stage colorectal cancer.
methodsPatients with stage I and low-risk stage II colorectal cancer, treated with radical surgery in a hospital setting between May 2003 and September 2014, were retrospectively reviewed. Patients who underwent (neo) adjuvant chemotherapy and/or radiotherapy and whose microsatellite instability (MSI) status was lacked were excluded. Distal colon cancer was defined as tumors located from the splenic flexure colon to the sigmoid colon.
resultsA total of 712 patients were included in this study. Of these patients, 23 (3.2%) had a recurrence at a median follow-up time of 46 months. The tumor recurrence rate was significantly low in patients with proximal colon cancer. In the multivariate analysis, tumors located in the distal colon or rectum (distal colon, hazard ratio [HR] 9.213, P = 0.035; rectum, HR 15.366, P = 0.009) and T3 tumors (HR 4.590, P = 0.017) were related to tumor recurrence. A higher prevalence of tumor recurrence was found in patients with two recurrence factors than those who had only one factor or none (P < 0.001).
conclusionsTumor location, as well as T stage, had prognostic implication in patients with early-stage colorectal cancer. Validation of our results is needed in a large cohort with genetic characterization.
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