Evidence map›Paper›PMID 29594415›Full record

ArticleImmunogenetics2018

Restricted MHC class I A locus diversity in olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center.

Rebecca A Morgan, Julie A Karl, Hailey E Bussan, Katelyn E Heimbruch, David H O'Connor, Dawn M Dudley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunogenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rebecca A MorganWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Julie A KarlDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Hailey E BussanDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Katelyn E HeimbruchWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
David H O'ConnorWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
Dawn M DudleyDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA. dmdudley@wisc.edu.
University of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI KAUFMAN, PAUL L · 1985 to 2011
$106.7M
EXTRAMURAL RES FACIL CONST: REPRODUCTIVE, GROWTH &DVMT, MENOPAUSEC06RR020141 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI CADWALLADER, MARTIN · 2004 to 2004
$3.6M
GENETICS LABORATORY RENOVATION PROJECTC06RR015450 · NCRR · DARTMOUTH COLLEGE · PI SPIELBERG, STEPHEN P · 2000 to 2000
$1.0M
NCRR NIH HHS C06 RR015450NCRR NIH HHS C06 RR020141NCRR NIH HHS P51 RR000167NIAID NIH HHS HHSN272201600007CNIH HHS P51 OD011106ODCDC CDC HHS P51 OD011106
6 · The paper itself

Abstract

Baboons are valuable models for complex human diseases due to their genetic and physiologic similarities to humans. Deep sequencing methods to characterize full-length major histocompatibility complex (MHC) class I (MHC-I) alleles in different nonhuman primate populations were used to identify novel MHC-I alleles in baboons. We combined data from Illumina MiSeq sequencing and Roche/454 sequencing to characterize novel full-length MHC-I transcripts in a cohort of olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center (SNPRC). We characterized 57 novel full-length alleles from 24 baboons and found limited genetic diversity at the MHC-I A locus, with significant sharing of two MHC-I A lineages between 22 out of the 24 animals characterized. These shared alleles provide the basis for development of tools such as MHC:peptide tetramers for studying cellular immune responses in this important animal model.

Indexed as

AllelesAnimalsGene FrequencyGenes, MHC Class IGenetic VariationHaplotypesHigh-Throughput Nucleotide SequencingHistocompatibility Antigens Class IMajor Histocompatibility ComplexPapio anubisPapio cynocephalusPhylogenyPrimatesHistocompatibility Antigens Class IBaboonIllumina MiSeq sequencingMajor histocompatibility complex IPapio anubisPapio anubis cynocephalusPapio hamadryasRoche/454 pyrosequencing

Identifiers

PMID29594415
PMCPMC8130456
OpenAlexW2794957156

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.