ArticleMikrochimica acta2017
Highly sensitive electrochemical DNA sensor based on the use of three-dimensional nitrogen-doped graphene.
Article in Mikrochimica acta, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- Nanocomposite of electrochemically reduced graphene oxide and gold nanourchins for electrochemical DNA detection.IET nanobiotechnology · 2022Article
- Evolution of nucleic acids biosensors detection limit III.Analytical and bioanalytical chemistry · 2022Review
- A single nucleotide polymorphism electrochemical sensor based on DNA-functionalized Cd-MOFs-74 as cascade signal amplification probes.Mikrochimica acta · 2021Article
- A sensitive electrochemiluminescence DNA biosensor based on the signal amplification of ExoIII enzyme-assisted hybridization chain reaction combined with nanoparticle-loaded multiple probes.Mikrochimica acta · 2021Article
- A novel biosensor for the ultrasensitive detection of the lncRNA biomarker MALAT1 in non-small cell lung cancer.Scientific reports · 2021Article
- Voltammetric determination of the antimalarial drug chloroquine using a glassy carbon electrode modified with reduced graphene oxide on WSMikrochimica acta · 2019Article
- Voltammetric determination of DNA based on regulation of DNA strand displacement using an allosteric DNA toehold.Mikrochimica acta · 2018Article
- Electrodes modified with 3D graphene composites: a review on methods for preparation, properties and sensing applications.Mikrochimica acta · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This paper describes a voltammetric method for sensitive determination of specific sequences of DNA. The assay is based on three-dimensional nitrogen-doped graphene (3D-NG) which, due to its excellent electrical conductivity, provides a favorable microenvironment to retain the activity of immobilized probe single-stranded DNA and also facilitates electron transfer. The free-standing 3D-NG electrode was characterized by scanning electron microscopy, Raman and X-ray photoelectron spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. Differential pulse voltammetry was applied to monitor DNA hybridization using Methylene Blue as an electrochemical indicator. Under optimal conditions, the peak currents (best measured at 0.28 V vs. Ag/AgCl) increase linearly with the logarithm of the concentrations of ssDNA in the 10 f. to 10 nM concentrations range, with a 3.5 f. detection limit (at a signal/noise ratio of 3). The biosensor exhibits good selectivity for ssDNA and can distinguish even single-base mismatches. The capability of the method was tested with spiked serum samples, and excellent reproducibility and stability is found. This indicates that the strategy is promising for use in clinical applications. Graphical abstract Three-dimensional nitrogen-doped graphene as an innovative and simple electrochemical DNA biosensor was fabricated and used in a biosensor that shows high sensitivity and good performance in the determination of target DNA in human serum samples.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.