Evidence map›Paper›PMID 29594229›Full record

ArticleClinical and translational radiation oncology2017

Radiomic analysis in prediction of Human Papilloma Virus status.

Kaixian Yu, Youyi Zhang, Yang Yu, Chao Huang, Rongjie Liu, Tengfei Li, Liuqing Yang, Jeffrey S Morris, Veerabhadran Baladandayuthapani, Hongtu Zhu

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational radiation oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  12. Yonsei medical journal · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kaixian YuDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, United States.
Youyi ZhangDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, United States.
Yang YuDepartment of Statistics and Operations Research, University of North Carolina at Chapel Hill, United States.
Chao HuangDepartment of Biostatistics, University of North Carolina at Chapel Hill, United States.
Rongjie LiuDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, United States.
Tengfei LiDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, United States.
Liuqing YangDepartment of Statistics and Operations Research, University of North Carolina at Chapel Hill, United States.
Jeffrey S MorrisDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, United States.
Veerabhadran BaladandayuthapaniDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, United States.
Hongtu ZhuDepartment of Biostatistics, The University of Texas M.D. Anderson Cancer Center, United States.
The University of Texas MD Anderson Cancer Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Statistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9M
Graph-based Bayesian analysis of Genomics and Proteomics DataR01CA194391 · NCI · TEXAS A&M UNIVERSITY · PI BALADANDAYUTHAPANI, VEERABHADRAN, MALLICK, BANI K · 2016 to 2020
$2.0M
Bayesian methods for complex, high-dimensional functional data in cancer researchR01CA178744 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MORRIS, JEFFREY S · 2015 to 2019
$1.7M
Integrative methods for high-dimensional genomics dataR01CA160736 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BALADANDAYUTHAPANI, VEERABHADRAN · 2011 to 2014
$1.4M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA160736NCI NIH HHS R01 CA178744NCI NIH HHS R01 CA194391NIMH NIH HHS R01 MH086633
6 · The paper itself

Abstract

Human Papilloma Virus (HPV) has been associated with oropharyngeal cancer prognosis. Traditionally the HPV status is tested through invasive lab test. Recently, the rapid development of statistical image analysis techniques has enabled precise quantitative analysis of medical images. The quantitative analysis of Computed Tomography (CT) provides a non-invasive way to assess HPV status for oropharynx cancer patients. We designed a statistical radiomics approach analyzing CT images to predict HPV status. Various radiomics features were extracted from CT scans, and analyzed using statistical feature selection and prediction methods. Our approach ranked the highest in the 2016 Medical Image Computing and Computer Assisted Intervention (MICCAI) grand challenge: Oropharynx Cancer (OPC) Radiomics Challenge, Human Papilloma Virus (HPV) Status Prediction. Further analysis on the most relevant radiomic features distinguishing HPV positive and negative subjects suggested that HPV positive patients usually have smaller and simpler tumors.

Indexed as

CT imageHPV statusOropharynx cancerRadiomicsStatistical method

Identifiers

PMID29594229
PMCPMC5862639
OpenAlexW2766461702

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.