ArticleClinical and translational radiation oncology2017
Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer.
Article in Clinical and translational radiation oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Review
- Therapeutic enhancement of radiation and immunomodulation by gold nanoparticles in triple negative breast cancer.Cancer biology & therapy · 2021Article
- Can the Adoption of Hypofractionation Guidelines Expand Global Radiotherapy Access? An Analysis for Breast and Prostate Radiotherapy.JCO global oncology · 2020Article
- Altered fractionation in radiation therapy for breast cancer in the elderly: are we moving forward?Translational cancer research · 2020Review
- Single dose partial breast irradiation using an MRI linear accelerator in the supine and prone treatment position.Clinical and translational radiation oncology · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundFollowing breast-conserving surgery and post-operative 3D-conformal accelerated partial breast irradiation (APBI), suboptimal cosmetic results have been reported. Preoperative radiation delivery to the intact tumor enables better target visualization and treatment volume reduction. Single dose preoperative APBI has the potential to improve toxicity profiles, reduce treatment burden and enable in vivo exploration of breast cancer radiogenomics. PURPOSE: Develop practical guidelines for single dose external beam preoperative APBI.
methodsRecommended dose constraints were derived from pooled dosimetry estimates from 2 clinical trials. In an American dose escalation trial, a uniform 15, 18 or 21 Gy dose has previously been evaluated for non-lobular cT1N0 or low/intermediate grade DCIS <2 cm in prone position (
resultsDosimetric data pooling enabled the development of practical guidelines for single dose preoperative APBI.
conclusionThe developed guidelines will allow further explorations in the promising field of single dose preoperative external beam APBI for breast cancer treatment.
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