Evidence map›Paper›PMID 29594181›Full record

ArticleJournal of medical imaging (Bellingham, Wash.)2018

Predicting malignant nodules by fusing deep features with classical radiomics features.

Rahul Paul, Samuel H Hawkins, Matthew B Schabath, Robert J Gillies, Lawrence O Hall, Dmitry B Goldgof

Open access · bronzeAbstract read
In one paragraph

Article in Journal of medical imaging (Bellingham, Wash.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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  11. Bibliometric analysis of the application of deep learning in cancer from 2015 to 2023.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
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  13. EJNMMI research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rahul PaulUniversity of South Florida, Department of Computer Science and Engineering, Tampa, Florida, United States.ORCID https://orcid.org/0000-0003-1491-1166
Samuel H HawkinsUniversity of South Florida, Department of Computer Science and Engineering, Tampa, Florida, United States.
Matthew B SchabathH. Lee Moffitt Cancer Center & Research Institute, Department of Cancer Epidemiology, Tampa, Florida, United States.ORCID https://orcid.org/0000-0003-3241-3216
Robert J GilliesH. Lee Moffitt Cancer Center & Research Institute, Department of Cancer Physiology, Tampa, Florida, United States.
Lawrence O HallUniversity of South Florida, Department of Computer Science and Engineering, Tampa, Florida, United States.ORCID https://orcid.org/0000-0002-7898-8456
Dmitry B GoldgofUniversity of South Florida, Department of Computer Science and Engineering, Tampa, Florida, United States.ORCID https://orcid.org/0000-0001-5461-863X
University of South Florida · USMoffitt Cancer Center · US

Funding

Quantitative Imaging Clinical Validation Center at Moffitt Cancer CenterU01CA200464 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JOHN J HEINE, Matthew B. Schabath · 2016 to 2026
$9.2M
Radiomics of NSCLCU01CA143062 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GILLIES, ROBERT J., SCHABATH, MATTHEW B. · 2010 to 2020
$5.7M
Informatics Tools for Optimized Imaging Biomarkers for Cancer Research&DiscoveryU24CA180927 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE, ROSEN, BRUCE R · 2014 to 2018
$3.4M
Quantitative MRI of Glioblastoma ResponseU01CA154601 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE · 2011 to 2016
$3.4M
Non-invasive evaluation of indeterminate pulmonary nodulesU01CA186145 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MASSION, PIERRE P. · 2015 to 2019
$2.0M
NCI NIH HHS U01 CA143062NCI NIH HHS U01 CA154601NCI NIH HHS U01 CA186145NCI NIH HHS U01 CA200464NCI NIH HHS U24 CA180927
6 · The paper itself

Abstract

Lung cancer has a high incidence and mortality rate. Early detection and diagnosis of lung cancers is best achieved with low-dose computed tomography (CT). Classical radiomics features extracted from lung CT images have been shown as able to predict cancer incidence and prognosis. With the advancement of deep learning and convolutional neural networks (CNNs), deep features can be identified to analyze lung CTs for prognosis prediction and diagnosis. Due to a limited number of available images in the medical field, the transfer learning concept can be helpful. Using subsets of participants from the National Lung Screening Trial (NLST), we utilized a transfer learning approach to differentiate lung cancer nodules versus positive controls. We experimented with three different pretrained CNNs for extracting deep features and used five different classifiers. Experiments were also conducted with deep features from different color channels of a pretrained CNN. Selected deep features were combined with radiomics features. A CNN was designed and trained. Combinations of features from pretrained, CNNs trained on NLST data, and classical radiomics were used to build classifiers. The best accuracy (76.79%) was obtained using feature combinations. An area under the receiver operating characteristic curve of 0.87 was obtained using a CNN trained on an augmented NLST data cohort.

Indexed as

convolutional neural networkdeep featuresNational Lung Screening Trialnonsmall cell lung cancerradiomicstransfer learning

Identifiers

PMID29594181
PMCPMC5862127
OpenAlexW2790973804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.