ArticleOpen forum infectious diseases2018
Influence of Reported Penicillin Allergy on Mortality in MSSA Bacteremia.
Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Assessment of the Frequency of Dual Allergy to Penicillins and Cefazolin: A Systematic Review and Meta-analysis.JAMA surgery · 2021Pooled it
- Differences in oxazolidinone resistance mechanisms and small colony variants emergence ofEmerging microbes & infections · 2024Article
- Examining Antimicrobial Stewardship Program Implementation in Carceral Settings.AMA journal of ethics · 2024Article
- Ethics of antibiotic allergy.Journal of medical ethics · 2023Article
- Article
- Challenges and opportunities related to penicillin allergy in the Veterans Health Administration: a narrative review.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Review
- Penicillin Allergy Label Is Associated With Worse Clinical Outcomes in Bacterial Pneumonia.The journal of allergy and clinical immunology. In practice · 2022Article
- Article
- Evaluation of a Pharmacist-Led Penicillin Allergy Assessment Program and Allergy Delabeling in a Tertiary Care Hospital.JAMA network open · 2021Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPenicillin allergy frequently impacts antibiotic choice. As beta-lactams are superior to vancomycin in treating methicillin-susceptible
methodsIn this retrospective cohort study of adults with MSSA bacteremia admitted to a large tertiary care hospital, outcomes were examined according to reported penicillin allergy. Primary outcomes included 30-day and 90-day mortality rates. Multivariable regression models were developed to quantify the effect of reported penicillin allergy on mortality while adjusting for potential confounders.
resultsFrom 2010 to 2015, 318 patients with MSSA bacteremia were identified. Reported penicillin allergy had no significant effect on adjusted 30-day mortality (odds ratio [OR], 0.73; 95% confidence interval [CI], 0.29-1.84;
conclusionsReported penicillin allergy had no significant effect on 30- or 90-day mortality. Non-penicillin-allergic patients receiving vancomycin for treatment of MSSA bacteremia had the highest mortality rates overall. Receipt of a beta-lactam was the strongest predictor of survival. These results underscore the importance of correct classification of patients with penicillin allergy and appropriate treatment with a beta-lactam when tolerated.
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Registered trials
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