ArticleFrontiers in medicine2018
Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection.
Article in Frontiers in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 18 citations in OpenAlex.
- Varicella-zoster virus infection triggering GD3 antibody-positive variant Guillain-Barré syndrome: a case report and literature review.BMC neurology · 2026Review
- Pathogenesis and clinical management of arboviral diseases.World journal of virology · 2025Review
- Zika Virus Neuropathogenesis-Research and Understanding.Pathogens (Basel, Switzerland) · 2024Review
- Guillain-barré syndrome (GBS) with antecedent chikungunya infection: a case report and literature review.Neurological research and practice · 2024Review
- SARS-CoV-2 infection-induced immunity reduces rates of reinfection and hospitalization caused by the Delta or Omicron variants.Emerging microbes & infections · 2023Observational
- Gangliosides in nervous system development, regeneration, and pathologies.Neural regeneration research · 2023Review
- Gangliosides as Biomarkers of Human Brain Diseases: Trends in Discovery and Characterization by High-Performance Mass Spectrometry.International journal of molecular sciences · 2022Review
- Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved.Frontiers in immunology · 2022Review
- Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections.Frontiers in immunology · 2022Review
- Antecedent infections in Guillain-Barré syndrome in endemic areas of arbovirus transmission: A multinational case-control study.Journal of the peripheral nervous system : JPNS · 2021Observational
- Emerging Infection, Vaccination, and Guillain-Barré Syndrome: A Review.Neurology and therapy · 2021Review
- Recombinant Antigens Based on Non-Glycosylated Regions from RBD SARS-CoV-2 as Potential Vaccine Candidates against COVID-19.Vaccines · 2021Article
- Review
- Physiology of gangliosides and the role of antiganglioside antibodies in human diseases.Cellular & molecular immunology · 2020Review
- Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil.PLoS neglected tropical diseases · 2019Article
- Metabolomic Insights into Human Arboviral Infections: Dengue, Chikungunya, and Zika Viruses.Viruses · 2019Review
- Divergent Roles of Antiself Antibodies during Infection.Trends in immunology · 2018Review
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
Abstract
Zika virus (ZIKV) disease has become a global health emergency with devastating effects on public health. Recent evidences implicate the virus as an emergent neuropathological agent promoting serious pathologies of the human nervous system, that include destructive and malformation consequences such as development of ocular and fetal brain lesions, microcephaly in neonates, and Guillain-Barré syndrome (GBS) in adults. These neurological disorders of both central and peripheral nervous systems are thought to be associated to the neurotropic properties of the virus that has ability to infect neural stem cells as well as peripheral neurons, a hallmark of its pathogenicity. The presence of autoantibodies against gangliosides plays a pivotal role in the etiogenesis of GBS and a variety of neurological disorders. Gangliosides are a class of galactose-containing cerebrosides mainly expressed in nervous system tissues playing a critical role in the physiology of neural cells and neurogenesis. Herein, our findings indicate that patients at acute phase of ZIKV infection without any neurological signs show increased levels of IgG autoantibody against GD3 gangliosides, a class of glycolipid found to be highly expressed in neural stem cell acting in the maintenance of their self-renewal cellular capacity. It is possible that a pathological threshold of these antibodies is only acquired in secondary or subsequent infections. In the light of these evidences, we propose that the target of GD3 by autoimmune responses may possibly has an effect in the neuropathy and neurogenesis disorder seen during ZIKV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.