Evidence map›Paper›PMID 29594051›Full record

ArticleEuropean thyroid journal2018

Vitamin D in Graves Disease: Levels, Correlation with Laboratory and Clinical Parameters, and Genetics.

Tereza Planck, Bushra Shahida, Johan Malm, Jonas Manjer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European thyroid journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  4. Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
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  6. Review
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  12. Article
  13. Absence of a relationship between vitamin D and Graves' orbitopathy.Journal of endocrinological investigation · 2023
    Article
  14. Article
  15. Review
  16. Vitamin D and bone metabolism in Graves' disease: a prospective study.Journal of endocrinological investigation · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tereza PlanckDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Bushra ShahidaDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Johan MalmDepartment of Translational Medicine, Section for Clinical Chemistry, Lund University, Malmö, Sweden.
Jonas ManjerDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD.

methodsThe levels of vitamin D were compared in 292 patients with newly diagnosed GD and 2,305 controls. Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR), vitamin D binding protein (DBP), and 1-α-hydroxylase (

resultsPatients with GD had significantly lower vitamin D levels compared to controls (55.0 ± 23.2 vs. 87.2 ± 27.6 nmol/L,

conclusionsPatients with GD had lower vitamin D levels compared to the general population; however, the vitamin D levels did not affect the laboratory or clinical parameters of GD. SNPs in the VDR influenced the risk of GD through mechanisms other than reducing the vitamin D levels.

Indexed as

Graves diseaseGraves ophthalmopathyVitamin DVitamin D receptor

Identifiers

PMID29594051
PMCPMC5836255
OpenAlexW2769805138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.