Evidence map›Paper›PMID 29594042›Full record

ArticleFrontiers in oncology2018

Biotherapies in Solid Tumors: Are Negative Results Still of Low Priority for Publication?

Alessandro Ottaiano, Antonino Cassata, Monica Capozzi, Chiara De Divitiis, Alfonso De Stefano, Antonio Avallone

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alessandro OttaianoDepartment of Abdominal Oncology, Istituto Nazionale Tumori Fondazione G. Pascale (IRCCS), Naples, Italy.
Antonino CassataDepartment of Abdominal Oncology, Istituto Nazionale Tumori Fondazione G. Pascale (IRCCS), Naples, Italy.
Monica CapozziDepartment of Abdominal Oncology, Istituto Nazionale Tumori Fondazione G. Pascale (IRCCS), Naples, Italy.
Chiara De DivitiisDepartment of Abdominal Oncology, Istituto Nazionale Tumori Fondazione G. Pascale (IRCCS), Naples, Italy.
Alfonso De StefanoDepartment of Abdominal Oncology, Istituto Nazionale Tumori Fondazione G. Pascale (IRCCS), Naples, Italy.
Antonio AvalloneDepartment of Abdominal Oncology, Istituto Nazionale Tumori Fondazione G. Pascale (IRCCS), Naples, Italy.
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2005, we performed the largest survey on clinical trials of biotherapies for all solid tumors and found indirect evidence of a publication bias: editors of medical journals were more prone to publish positive results independently from the quality of the studies. We collected data from 2003 to 2015 in 487 studies, and the publication bias previously described was not found in the years between 2010 and 2015: this could be related to changes and/or innovations in the guidelines and editorial policies of oncology journals occurred over the last years.

Indexed as

biotherapiesmethodologypublication biassolid tumorssurvey

Identifiers

PMID29594042
PMCPMC5861183
OpenAlexW2789841537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.