ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018
Multiplex Photoluminescent Silicon Nanoprobe for Diagnostic Bioimaging and Intracellular Analysis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Progress and Applications of Nanocomposites in the Technology of Biosensors.Nanomaterials (Basel, Switzerland) · 2025Review
- Core-Shell Interface Engineering Strategies for Modulating Energy Transfer in Rare Earth-Doped Nanoparticles.Nanomaterials (Basel, Switzerland) · 2024Article
- Silver-Assisted Chemical Etching for the Fabrication of Porous Silicon N-Doped Nanohollow Carbon Spheres Composite Anodes to Enhance Electrochemical Performance.Materials (Basel, Switzerland) · 2024Article
- Laser Ablation of Silicon Nanoparticles and Their Use in Charge-Coupled Devices for UV Light Sensing via Wavelength-Shifting Properties.Nanomaterials (Basel, Switzerland) · 2023Article
- Fluorogenic Reactions in Chemical Biology: Seeing Chemistry in Cells.Chemical & biomedical imaging · 2023Review
- Intravital Microscopy Reveals Endothelial Transcytosis Contributing to Significant Tumor Accumulation of Albumin Nanoparticles.Pharmaceutics · 2023Article
- Application of Various Optical and Electrochemical Nanobiosensors for Detecting Cancer Antigen 125 (CA-125): A Review.Biosensors · 2023Review
- Nano-Scaled Materials and Polymer Integration in Biosensing Tools.Biosensors · 2022Review
- Nanomaterial-Based Dual-Emission Ratiometric Fluorescent Sensors for Biosensing and Cell Imaging.Polymers · 2021Review
- Application of Halloysite Nanotubes in Cancer Therapy-A Review.Materials (Basel, Switzerland) · 2021Review
- Biomedical Waste Management by Using Nanophotocatalysts: The Need for New Options.Materials (Basel, Switzerland) · 2020Review
- Multiplex Photoluminescent Silicon Nanoprobe for Diagnostic Bioimaging and Intracellular Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, a label-free multiplex photoluminescent silicon nanoprobe (PLSN-probe) is introduced as a potential substitute for quantum dots (QDs) in bioimaging. An inherently non-photoluminescent silicon substrate is altered to create the PLSN-probe, to overcome the major drawbacks of presently available QDs. Additionally, crystallinity alterations of the multiplane crystalline PLSN-probes lead to broad absorption and multiplex fluorescence emissions, which are attributed to the simultaneous existence of multiple crystal planes. The PLSN-probe not only demonstrates unique optical properties that can be exploited for bioimaging but also exhibits cell-selective uptake that allows the differentiation and diagnosis of HeLa and fibroblast cells. Moreover, multiplex emissions of the PLSN-probe illuminate different organelles such as the nucleus, nucleolemma, and cytoskeleton, depending on size-based preferential uptake by the cell organs. This in vitro study reveals that cancerous HeLa cells have a higher propensity for taking up the PLSN-probe compared to fibroblast cells, allowing the diagnosis of cancerous HeLa cells. Additionally, the fluorescence intensity per unit area of the cell is found to be a reliable means for distinguishing between dead and healthy cells. It is anticipated that the multifunctionality of the PLSN-probes will lead to better insight into the use of such probes for bioimaging and diagnosis applications.
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Registered trials
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