ArticleRMD open2018
Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment.
Article in RMD open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Trial
- Association of Biologic/Targeted-Synthetic DMARDs with a Lower Prevalence of Hand Joint Deformity in Rheumatoid Arthritis: A Cross-Sectional Real-World Study.Medicina (Kaunas, Lithuania) · 2026Article
- Elevated Serum Levels of YKL-40, YKL-39, and SI-CLP in Patients with Treatment Failure to DMARDs in Patients with Rheumatoid Arthritis.Biomedicines · 2024Article
- The perspective of Polish patients with rheumatoid arthritis - treatment expectations, patient-reported outcomes, and digital literacy (the SENSE study).Reumatologia · 2023Article
- Direct healthcare resource utilisation, health-related quality of life, and work productivity in patients with moderate rheumatoid arthritis: an observational study.BMC musculoskeletal disorders · 2021Observational
- Treatment Satisfaction, Patient Preferences, and the Impact of Suboptimal Disease Control in a Large International Rheumatoid Arthritis Cohort: SENSE Study.Patient preference and adherence · 2021Article
- Empirical evidence of disease activity thresholds used to indicate need for major therapeutic change in US veterans with rheumatoid arthritis.Arthritis research & therapy · 2020Article
- Transforming clinical trials in rheumatology: towards patient-centric precision medicine.Nature reviews. Rheumatology · 2020Review
- The Valued Life Activities Scale (VLAs): linguistic validation, cultural adaptation and psychometric testing in people with rheumatic and musculoskeletal diseases in the UK.BMC musculoskeletal disorders · 2020Article
- Minimizing efficacy differences between phase II and III RCTs.Nature reviews. Rheumatology · 2020Article
- Levels of satisfaction with rheumatoid arthritis treatment and associated alignment between physicians and patients across Latin America.Clinical rheumatology · 2020Article
- ASIC1a induces synovial inflammation via the CaTheranostics · 2020Article
- [Higher prevalence of depressive and anxiety symptoms in early arthritis patients in comparison to the normal population].Zeitschrift fur Rheumatologie · 2019Article
- Physician Adherence to Treat-to-Target and Practice Guidelines in Rheumatoid Arthritis.Journal of clinical medicine · 2019Review
- Comorbidity burden and clinical characteristics of patients with difficult-to-control rheumatoid arthritis.Clinical rheumatology · 2019Article
- Serum P-glycoprotein level: a potential biomarker of DMARD failure in patients with rheumatoid arthritis.Inflammopharmacology · 2018Article
- Factors influencing the use of biologic therapy and adoption of treat-to-target recommendations in current European rheumatology practice.Patient preference and adherence · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the wide array of treatments available for rheumatoid arthritis (RA), some patients continue to report unmet clinical needs. We investigated the extent of inadequate disease control in patients with RA.
methodsData were drawn from the Adelphi 2014 RA Disease-Specific Program in France, Germany, Italy, Spain and the UK. Rheumatologists provided patient demographics, comorbidities, satisfaction with RA control and other clinical details. Patients reported their level of satisfaction and completed the EuroQoL 5-Dimensions Health Questionnaire and Work Productivity and Activity Impairment Questionnaire. Patients had been on their current therapy ≥3 months and had 28-joint disease activity scores (DAS28) reported. Adequately controlled (DAS28 ≤3.2) and inadequately controlled (DAS28 >3.2) patient cohorts were compared using univariate tests.
resultsOf 1147 patients, 74% were women, the mean age was 52 years and the mean time since RA diagnosis was 7 years. Twenty-seven percent of patients had inadequately controlled RA, whereas 73% had adequately controlled RA. Inadequately controlled patients were more affected clinically versus adequately controlled patients; 69% vs 13% had moderate/severe RA, the current level of pain was 4.6 vs 2.3, and 67% vs 41% experienced flares, respectively (all p<0.0001). Inadequately controlled patients had higher rates of depression (16% vs 5%; p<0.0001), worse health state, greater work and activity impairment, and lower satisfaction rates among the patients and their physicians than the adequately controlled cohort.
conclusionRA was insufficiently controlled in over a quarter of patients despite their current therapy and this had a negative impact on the patients.
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