Evidence map›Paper›PMID 29593850›Full record

ArticleInternational journal of physiology, pathophysiology and pharmacology2018

Systemic delivery of selective EP1 and EP3 receptor antagonists attenuates pentylenetetrazole-induced seizures in mice.

Cristina R Reschke, Alice B Poersch, Cíntia J Masson, Ana C Jesse, Joseane R Marafiga, Quéli F Lenz, Mauro S Oliveira, David C Henshall, Carlos F Mello

Open access · greenAbstract read
In one paragraph

Article in International journal of physiology, pathophysiology and pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Neuroinflammatory mediators in acquired epilepsy: an update.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  2. Review
  3. Insights into Potential Targets for Therapeutic Intervention in Epilepsy.International journal of molecular sciences · 2020
    Review
  4. Review
  5. The COX-2/prostanoid signaling cascades in seizure disorders.Expert opinion on therapeutic targets · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Cristina R ReschkeDepartment of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria (UFSM)Santa Maria, 97105-900, RS, Brazil.
Alice B PoerschDepartment of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria (UFSM)Santa Maria, 97105-900, RS, Brazil.
Cíntia J MassonDepartment of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria (UFSM)Santa Maria, 97105-900, RS, Brazil.
Ana C JesseDepartment of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria (UFSM)Santa Maria, 97105-900, RS, Brazil.
Joseane R MarafigaDepartment of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria (UFSM)Santa Maria, 97105-900, RS, Brazil.
Quéli F LenzDepartment of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria (UFSM)Santa Maria, 97105-900, RS, Brazil.
Mauro S OliveiraDepartment of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria (UFSM)Santa Maria, 97105-900, RS, Brazil.
David C HenshallDepartment of Physiology and Medical Physics, Royal College of Surgeons in Ireland123 St. Stephen's Green, Dublin 2, Irelsand.
Carlos F MelloDepartment of Physiology and Pharmacology, Center of Health Sciences, Federal University of Santa Maria (UFSM)Santa Maria, 97105-900, RS, Brazil.
Universidade Federal de Santa Maria · BRRoyal College of Surgeons in Ireland · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroinflammation plays a major role in brain excitability and may contribute to the development of epilepsy. Prostaglandin E

Indexed as

EP1 receptorEP3 receptorEpilepsypentylenetetrazoleprostaglandin E2

Identifiers

PMID29593850
PMCPMC5871629
OpenAlexW2950126123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.