ArticleArchives of medical science : AMS2018
Age-related differences in function and structure of rat livers subjected to ischemia/reperfusion.
Article in Archives of medical science : AMS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
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- The Prevention of Ischemia-Reperfusion Injury in Elderly Rats after Lower Limb Tourniquet Use.Antioxidants (Basel, Switzerland) · 2022Article
- Genetic polymorphism and antioxidant activity in interventions of tobacco-related diseases of the abdominal aorta.Archives of medical science : AMS · 2022Article
- Redox metabolism correlates with cellular turnover and clinical phenotype of papillary thyroid carcinoma and colloid goiter.Archives of medical science : AMS · 2022Article
- Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries?Archives of medical science : AMS · 2022Article
- Acute liver failure secondary to toxic exposure in children.Archives of medical science : AMS · 2022Article
- MicroRNA 144 inhibits cell migration and invasion and regulates inflammatory cytokine secretion through targeting toll like receptor 2 in non-small cell lung cancer.Archives of medical science : AMS · 2021Article
- Oxidative stress, immunological and cellular hypoxia biomarkers in hepatitis C treatment-naïve and cirrhotic patients.Archives of medical science : AMS · 2021Article
- BothArchives of medical science : AMS · 2021Article
- Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats.Archives of medical science : AMS · 2020Article
- Transcription coactivator p300 promotes inflammation by enhancing p65 subunit activation in type 2 diabetes nephropathy.International journal of clinical and experimental pathology · 2019Article
- Sitagliptin-Dependent Differences in the Intensity of Oxidative Stress in Rat Livers Subjected to Ischemia and Reperfusion.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLiver function is affected during ischemia/reperfusion (IR). The current state of knowledge about liver aging processes during IR is incomplete. We evaluated the effects of aging on liver structure and function under IR conditions. MATERIAL AND
methodsAnimals were divided into control (C-2) and ischemia/reperfusion (IR-2) groups of young rats (2-4 months old) and C-12 and IR-12 groups of old rats (12-14 months old). The livers from IR-2 and IR-12 groups were subjected to partial ischemia (60 min), followed by global reperfusion (4 h). Blood samples were obtained during reperfusion (0, 30 and 240 min) to estimate the activity of aminotransferases (ALT, AST). After IR, tumor necrosis factor-α (TNF-α), interleukin-1b (IL-1b), malondialdehyde (MDA), and superoxide dismutase (SOD) were determined in liver homogenates.
resultsAt all points of reperfusion, an increase in aminotransferase activity levels in the ischemic groups was observed; mainly between IR-12 and C-12 rats. The concentration of TNF-α was significantly higher in young animals (in non-ischemic groups:
conclusionsThe function and structure of mature livers slightly deteriorate with age and these differences are more noticeable under IR conditions.
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