Evidence map›Paper›PMID 29593794›Full record

ArticleInternational journal of dentistry2018

Comparative Analysis of the Effectiveness of the Topical Administration of Benzocaine and EMLA

David Gomes de Alencar Gondim, Antonio Marcos Montagner, Ivo Cavalcante Pita-Neto, Romildo José de Siqueira Bringel, Francisco Aurelio Luchesi Sandrini, Eduardo Fernando Chaves Moreno, Amanda Mendes de Sousa, Andreza Bastos Correia

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of dentistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06165432 (Effectiveness of Pre Injection Use of Cryoanesthesia as Compared to Topical Anesthetic Gel in Reducing Pain Perception During Palatal Injections), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06165432 phase4completednot on this mapstarted 2021, after this paper: background citation

Effectiveness of Pre Injection Use of Cryoanesthesia as Compared to Topical Anesthetic Gel in Reducing Pain Perception During Palatal Injections

TypeinterventionalSponsorB.P. Koirala Institute of Health SciencesRan2021 to 2022Enrolled60ConditionsPainArmsTopical Benzocaine, Topical ice
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David Gomes de Alencar GondimSão Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.ORCID 0000-0001-6116-3856
Antonio Marcos MontagnerSão Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil.
Ivo Cavalcante Pita-NetoSchool of Dentistry, UNILEÃO-University Center, Juazeiro do Norte, CE, Brazil.
Romildo José de Siqueira BringelSchool of Dentistry, UNILEÃO-University Center, Juazeiro do Norte, CE, Brazil.
Francisco Aurelio Luchesi SandriniSchool of Dentistry, UNILEÃO-University Center, Juazeiro do Norte, CE, Brazil.
Eduardo Fernando Chaves MorenoSchool of Dentistry, UNILEÃO-University Center, Juazeiro do Norte, CE, Brazil.
Amanda Mendes de SousaSchool of Dentistry, UNILEÃO-University Center, Juazeiro do Norte, CE, Brazil.
Andreza Bastos CorreiaSchool of Dentistry, UNILEÃO-University Center, Juazeiro do Norte, CE, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare the effectiveness of the topical administration of benzocaine and EMLA on oral pain and tactile sensitivity. MATERIALS AND

methodsA randomized, double-blind, split-mouth clinical trial was carried out with 20 volunteers. The sensorial and quantitative tests were applied before the contact with topical anesthetic and after the application.

resultsIn the superficial tactile perception test, when we compared each group singly, there were statistically significant values in the decrease of superficial tactile perception when compared to the moment prior to the application of anesthetic agents. For the sensitivity to mechanical pain, no statistical significant difference was observed at evaluated times. In the needle penetration test, in an intergroup analysis, we found a decrease in the pain sensitivity to needle penetration at 5 min (

conclusionThe application of topical anesthetic drugs reduces the discomfort associated with this procedure, mainly until the first 10 minutes. Only the needle penetration sensitivity test showed sufficient sensitivity to reveal a difference in the anesthetic effect between EMLA and benzocaine. This trial is registered with RBR-2N2GSW.

Identifiers

PMID29593794
PMCPMC5821963

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.