Evidence map›Paper›PMID 29593747›Full record

ArticleFrontiers in immunology2018

Whole-Inactivated Influenza Virus Is a Potent Adjuvant for Influenza Peptides Containing CD8

Peter C Soema, Sietske K Rosendahl Huber, Geert-Jan Willems, Ronald Jacobi, Marion Hendriks, Ernst Soethout, Wim Jiskoot, Jørgen de Jonge, Josine van Beek, Gideon F A Kersten and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Thioamide Analogues of MHC I Antigen Peptides.Journal of the American Chemical Society · 2023
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Peter C SoemaIntravacc (Institute for Translational Vaccinology), Bilthoven, Netherlands.
Sietske K Rosendahl HuberCentre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Geert-Jan WillemsIntravacc (Institute for Translational Vaccinology), Bilthoven, Netherlands.
Ronald JacobiCentre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Marion HendriksCentre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Ernst SoethoutIntravacc (Institute for Translational Vaccinology), Bilthoven, Netherlands.
Wim JiskootDivision of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, Netherlands.
Jørgen de JongeCentre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Josine van BeekCentre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Gideon F A KerstenIntravacc (Institute for Translational Vaccinology), Bilthoven, Netherlands.
Jean-Pierre AmorijIntravacc (Institute for Translational Vaccinology), Bilthoven, Netherlands.
Intravacc (Netherlands) · NLNational Institute for Public Health and the Environment · NLCentre for Human Drug Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza peptide antigens coding for conserved T cell epitopes have the capacity to induce cross-protective influenza-specific immunity. Short peptide antigens used as a vaccine, however, often show poor immunogenicity. In this study, we demonstrate that whole-inactivated influenza virus (WIV) acts as an adjuvant for influenza peptide antigens, as shown by the induction of peptide-specific CD8

Indexed as

Adjuvants, ImmunologicInfluenza A Virus, H5N1 SubtypeVirus InactivationAnimalsAntigens, ViralCD8-Positive T-LymphocytesEpitopes, T-LymphocyteFemaleMice, TransgenicPeptidesAdjuvants, ImmunologicAntigens, ViralEpitopes, T-LymphocytePeptidesadjuvantCTLdesign of experimentsformulationpeptide vaccineT cell peptidewhole-inactivated influenza virus

Identifiers

PMID29593747
PMCPMC5861146
OpenAlexW2790282567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.