Evidence map›Paper›PMID 29593732›Full record

ArticleFrontiers in immunology2018

A Distinct T Follicular Helper Cell Subset Infiltrates the Brain in Murine Neuropsychiatric Lupus.

Shweta Jain, Ariel Stock, Fernando Macian, Chaim Putterman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Towards precision medicine for systemic lupus erythematosus and neuropsychiatric manifestations.Expert review of precision medicine and drug development · 2025
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  17. T lymphocytes in IgA nephropathy.Experimental and therapeutic medicine · 2020
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shweta JainDivision of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, United States.
Ariel StockDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.
Fernando MacianDepartment of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States.
Chaim PuttermanDivision of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, United States.
Albert Einstein College of Medicine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Molecular mechanisms of T cell anergyR01AI059738 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI MACIAN, FERNANDO · 2004 to 2014
$3.9M
The role of TWEAK and Fn14 in the Pathogenesis and Treatment of NeuropsychiatricR01AR065594 · NIAMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PUTTERMAN, CHAIM · 2014 to 2018
$2.4M
NIAID NIH HHS R01 AI059738NIAMS NIH HHS R01 AR065594NIGMS NIH HHS T32 GM007288
6 · The paper itself

Abstract

Neuropsychiatric symptoms in systemic lupus erythematosus (SLE) are not uncommon, yet the mechanisms underlying disease initiation and progression in the brain are incompletely understood. Although the role of T cells in other lupus target organs such as the kidney is well defined, which T cells contribute to the pathogenesis of neuropsychiatric SLE is not known. The present study was aimed at characterizing the CD4 T cell populations that are present in the choroid plexus (CP) of MRL/MpJ-fas

Indexed as

AnimalsChoroid PlexusInterferon-gammaInterleukin-21InterleukinsLupus Vasculitis, Central Nervous SystemMiceMice, Inbred MRL lprProto-Oncogene Proteins c-bcl-6T-Lymphocytes, Helper-InducerBcl6 protein, mouseIFNG protein, mouseInterferon-gammaInterleukin-21InterleukinsProto-Oncogene Proteins c-bcl-6choroid plexusMRL/lprneuropsychiatric lupussystemic lupus erythematosusT follicular helper cells

Identifiers

PMID29593732
PMCPMC5859360
OpenAlexW2792151143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.