Evidence map›Paper›PMID 29593657›Full record

ArticleFrontiers in endocrinology2018

Lipoprotein Lipase Expression in Hypothalamus Is Involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure.

Elise Laperrousaz, Raphaël G Denis, Nadim Kassis, Cristina Contreras, Miguel López, Serge Luquet, Céline Cruciani-Guglielmacci, Christophe Magnan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Brain Nutrient Sensing: A Unifying Framework.Annual review of physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Elise LaperrousazUnité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Sorbonne Paris Cité, Université Denis Diderot, Paris, France.
Raphaël G DenisUnité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Sorbonne Paris Cité, Université Denis Diderot, Paris, France.
Nadim KassisUnité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Sorbonne Paris Cité, Université Denis Diderot, Paris, France.
Cristina ContrerasNeurObesity Group, Department of Physiology, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.
Miguel LópezNeurObesity Group, Department of Physiology, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain.
Serge LuquetUnité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Sorbonne Paris Cité, Université Denis Diderot, Paris, France.
Céline Cruciani-GuglielmacciUnité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Sorbonne Paris Cité, Université Denis Diderot, Paris, France.
Christophe MagnanUnité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Sorbonne Paris Cité, Université Denis Diderot, Paris, France.
Centre National de la Recherche Scientifique · FRCenter for Research in Molecular Medicine and Chronic Diseases · ESUnit of Functional and Adaptive Biology · FRSorbonne Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein lipase (LPL) is expressed in different areas of the brain, including the hypothalamus and plays an important role in neural control of the energy balance, including feeding behavior and metabolic fluxes. This study tested the hypothesis that hypothalamic LPL participates in the control of body temperature. We first showed that cold exposure induces decreased activity and expression of LPL in the mouse hypothalamus. We then selectively deleted LPL in the mediobasal hypothalamus (MBH) through an adeno-associated virus approach in LPL-floxed mice and generated MBHΔ

Indexed as

brown adipose tissuebrowning of white adipose tissuecold exposurehypothalamuslipoprotein lipase

Identifiers

PMID29593657
PMCPMC5861133
OpenAlexW2790810037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.