ArticleFrontiers in neurology2018
Quantitative Limbic System Mapping of Main Cognitive Domains in Multiple Sclerosis.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Correlation of cognitive dysfunctions and diffusion tensor MRI measures in subjects with RRMS.Frontiers in aging neuroscience · 2025Pooled it
- Interleukin-6 is correlated with amygdala volume and depression severity in adolescents and young adults with first-episode major depressive disorder.Brain imaging and behavior · 2024Article
- One-year regional brain volume changes as potential predictors of cognitive function in multiple sclerosis: a pilot study.Irish journal of medical science · 2024Article
- Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis.Journal of personalized medicine · 2021Article
- Altered Functional Connectivity in White and Gray Matter in Patients With Multiple Sclerosis.Frontiers in human neuroscience · 2020Article
- Voxel-based analysis of gray matter relaxation rates shows different correlation patterns for cognitive impairment and physical disability in relapsing-remitting multiple sclerosis.NeuroImage. Clinical · 2020Article
- Association Between White Matter Microstructure and Verbal Fluency in Patients With Multiple Sclerosis.Frontiers in psychology · 2019Article
- Yakovlev's Basolateral Limbic Circuit in Multiple Sclerosis Related Cognitive Impairment.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveCognitive impairment (CI) is common in multiple sclerosis (MS), but underlying mechanisms and their imaging correlates are not completely understood. The gray and white matter structures of the limbic system (LS) play crucial roles in different aspects of cognition. To investigate their role in MS related CI, and since a detailed evaluations are lacking in the literature, we used a comprehensive neuroimaging approach to evaluate CI's correlations with the main components of the LS.
methodsTen non-cognitively impaired MS patients and 30 MS patients with diagnosed CI, who underwent a comprehensive neuropsychological evaluation were included in the analysis. Microstructural integrity, volumetry of main limbic gray and white matter structures and cortical thickness were assessed for associations with CI.
resultsFornix and cingulum/cingulate cortices were found to be the strongest correlates of CI in MS. As expected, LS' gray and white matter structures were involved in various cognitive functions. Uncinate fasciculi showed significant correlation with verbal and visuospatial learning and memory, phonemic and semantic fluency; hippocampi with visuospatial skills, phonemic and semantic fluency, executive functions, and processing speed; thalami with verbal learning, visuospatial skills, semantic fluency; and amygdala with verbal recognition discrimination.
conclusionThis comprehensive neuroimaging approach elucidated the role of the main limbic structures in cognitive functions associated with MS-related CI.
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