ArticleFrontiers in aging neuroscience2018
Functional Hemispheric (A)symmetries in the Aged Brain-Relevance for Working Memory.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Exploring the Effects of EEG-Based Alpha Neurofeedback on Working Memory Capacity in Healthy Participants.Bioengineering (Basel, Switzerland) · 2023Article
- Article
- Asymmetrical subcortical plasticity entails cognitive progression in older individuals.Aging cell · 2019Article
- Deep Learning and Multiplex Networks for Accurate Modeling of Brain Age.Frontiers in aging neuroscience · 2019Article
- Functional MRI on executive functioning in aging and dementia: A scoping review of cognitive tasks.Aging medicine (Milton (N.S.W)) · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional hemispheric asymmetries have been described in different cognitive processes, such as decision-making and motivation. Variations in the pattern of left/right activity have been associated with normal brain functioning, and with neuropsychiatric diseases. Such asymmetries in brain activity evolve throughout life and are thought to decrease with aging, but clear associations with cognitive function have never been established. Herein, we assessed functional laterality during a working memory task (N-Back) in a healthy aging cohort (over 50 years old) and associated these asymmetries with performance in the test. Activity of lobule VI of the cerebellar hemisphere and angular gyrus was found to be lateralized to the right hemisphere, while the precentral gyrus presented left > right activation during this task. Interestingly, 1-Back accuracy was positively correlated with left > right superior parietal lobule activation, which was mostly due to the influence of the left hemisphere. In conclusion, although regions were mostly symmetrically activated during the N-Back task, performance in working memory in aged individuals seems to benefit from lateralized involvement of the superior parietal lobule.
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Registered trials
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